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8-Methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e] pyrazine-4-ones: highly in vivo potent and selective AMPA receptor antagonists.
Jimonet P, Chevé M, Bohme GA, Boireau A, Damour D, Debono MW, Genevois-Borella A, Imperato A, Pratt J, Randle JC, Ribeill Y, Stutzmann JM, Vuilhorgne M, Mignani S. Jimonet P, et al. Among authors: mignani s. Bioorg Med Chem. 2000 Aug;8(8):2211-7. doi: 10.1016/s0968-0896(00)00161-9. Bioorg Med Chem. 2000. PMID: 11003165
4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity.
Stutzmann JM, Bohme GA, Boireau A, Damour D, Debono MW, Genevois-Borella A, Imperato A, Jimonet P, Pratt J, Randle JC, Ribeill Y, Vuilhorgne M, Mignani S. Stutzmann JM, et al. Among authors: mignani s. Bioorg Med Chem Lett. 2000 May 15;10(10):1133-7. doi: 10.1016/s0960-894x(00)00181-5. Bioorg Med Chem Lett. 2000. PMID: 10843235
Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]inden.
Pratt J, Jimonet P, Bohme GA, Boireau A, Damour D, Debono MW, Genevois-Borella A, Randle JC, Ribeill Y, Stutzmann JM, Vuilhorgne M, Mignani S. Pratt J, et al. Among authors: mignani s. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2749-54. doi: 10.1016/s0960-894x(00)00561-8. Bioorg Med Chem Lett. 2000. PMID: 11133083
Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action.
Jimonet P, Bohme GA, Bouquerel J, Boireau A, Damour D, Debono MW, Genevois-Borella A, Hardy JC, Hubert P, Manfré F, Nemecek P, Pratt J, Randle JC, Ribeill Y, Stutzmann JM, Vuilhorgne M, Mignani S. Jimonet P, et al. Among authors: mignani s. Bioorg Med Chem Lett. 2001 Jan 22;11(2):127-32. doi: 10.1016/s0960-894x(00)00592-8. Bioorg Med Chem Lett. 2001. PMID: 11206442
Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz.
Stutzmann JM, Bohme GA, Boireau A, Damour D, Debono MW, Genevois-Borella A, Jimonet P, Pratt J, Randle JC, Ribeill Y, Vuilhorgne M, Mignani S. Stutzmann JM, et al. Among authors: mignani s. Bioorg Med Chem Lett. 2001 May 7;11(9):1205-10. doi: 10.1016/s0960-894x(01)00180-9. Bioorg Med Chem Lett. 2001. PMID: 11354378
144 results