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Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
Leclerc S, Garnier M, Hoessel R, Marko D, Bibb JA, Snyder GL, Greengard P, Biernat J, Wu YZ, Mandelkow EM, Eisenbrand G, Meijer L. Leclerc S, et al. Among authors: hoessel r. J Biol Chem. 2001 Jan 5;276(1):251-60. doi: 10.1074/jbc.M002466200. J Biol Chem. 2001. PMID: 11013232 Free article.
ChEMU 2020: Natural Language Processing Methods Are Effective for Information Extraction From Chemical Patents.
He J, Nguyen DQ, Akhondi SA, Druckenbrodt C, Thorne C, Hoessel R, Afzal Z, Zhai Z, Fang B, Yoshikawa H, Albahem A, Cavedon L, Cohn T, Baldwin T, Verspoor K. He J, et al. Among authors: hoessel r. Front Res Metr Anal. 2021 Mar 25;6:654438. doi: 10.3389/frma.2021.654438. eCollection 2021. Front Res Metr Anal. 2021. PMID: 33870071 Free PMC article.
Randomized phase II study of docetaxel versus doxorubicin in first- and second-line chemotherapy for locally advanced or metastatic soft tissue sarcomas in adults: a study of the european organization for research and treatment of cancer soft tissue and bone sarcoma group.
Verweij J, Lee SM, Ruka W, Buesa J, Coleman R, van Hoessel R, Seynaeve C, di Paola ED, van Glabbeke M, Tonelli D, Judson IR. Verweij J, et al. Among authors: van hoessel r. J Clin Oncol. 2000 May;18(10):2081-6. doi: 10.1200/JCO.2000.18.10.2081. J Clin Oncol. 2000. PMID: 10811673 Clinical Trial.