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Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
Leclerc S, Garnier M, Hoessel R, Marko D, Bibb JA, Snyder GL, Greengard P, Biernat J, Wu YZ, Mandelkow EM, Eisenbrand G, Meijer L. Leclerc S, et al. Among authors: meijer l. J Biol Chem. 2001 Jan 5;276(1):251-60. doi: 10.1074/jbc.M002466200. J Biol Chem. 2001. PMID: 11013232 Free article.
Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine.
De Azevedo WF, Leclerc S, Meijer L, Havlicek L, Strnad M, Kim SH. De Azevedo WF, et al. Among authors: meijer l. Eur J Biochem. 1997 Jan 15;243(1-2):518-26. doi: 10.1111/j.1432-1033.1997.0518a.x. Eur J Biochem. 1997. PMID: 9030780 Free article.
Roscovitine displays high efficiency and high selectivity (Meijer, L., Borgne, A., Mulner, O., Chong, J. P. J., Blow, J. J., Inagaki, N., Inagaki, M., Delcros, J....
Roscovitine displays high efficiency and high selectivity (Meijer, L., Borgne, A., Mulner, O., Chong, J. P. J., Blow, J. J., I …
Chemical inhibitors of cyclin-dependent kinases.
Meijer L, Kim SH. Meijer L, et al. Methods Enzymol. 1997;283:113-28. doi: 10.1016/s0076-6879(97)83011-x. Methods Enzymol. 1997. PMID: 9251015 No abstract available.
479 results