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Fusion of influenza virus with the endosomal membrane is inhibited by monoclonal antibodies to defined epitopes on the hemagglutinin.
Imai M, Sugimoto K, Okazaki K, Kida H. Imai M, et al. Among authors: kida h. Virus Res. 1998 Feb;53(2):129-39. doi: 10.1016/s0168-1702(97)00143-3. Virus Res. 1998. PMID: 9620205
The results support the hypothesis that anti-HA MAbs which lack HI activity neutralize viral infectivity by interfering with the low pH-induced conformational change in the HA molecule, resulting in inhibition of the fusion step in the viral replication process (Kida, H
The results support the hypothesis that anti-HA MAbs which lack HI activity neutralize viral infectivity by interfering with the low pH-indu …
971 results