Sauna ZE - Search Results

1

Synthesis and preliminary analysis of a P-glycoprotein-specific [3H]-benzophenone photoaffinity label based on (-)-stipiamide.

Andrus MB, Turner TM, Sauna ZE, Ambudkar SV. Andrus MB, et al. Among authors: sauna ze. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2275-8. doi: 10.1016/s0960-894x(00)00439-x. Bioorg Med Chem Lett. 2000. PMID: 11055337

2

The synthesis and evaluation of a solution phase indexed combinatorial library of non-natural polyenes for reversal of P-glycoprotein mediated multidrug resistance.

Andrus MB, Turner TM, Sauna ZE, Ambudkar SV. Andrus MB, et al. Among authors: sauna ze. J Org Chem. 2000 Aug 11;65(16):4973-83. doi: 10.1021/jo000453m. J Org Chem. 2000. PMID: 10956480

3

Biochemical basis of polyvalency as a strategy for enhancing the efficacy of P-glycoprotein (ABCB1) modulators: stipiamide homodimers separated with defined-length spacers reverse drug efflux with greater efficacy.

Sauna ZE, Andrus MB, Turner TM, Ambudkar SV. Sauna ZE, et al. Biochemistry. 2004 Mar 2;43(8):2262-71. doi: 10.1021/bi035965k. Biochemistry. 2004. PMID: 14979722

4

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein.

Sauna ZE, Ambudkar SV. Sauna ZE, et al. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2515-20. doi: 10.1073/pnas.97.6.2515. Proc Natl Acad Sci U S A. 2000. PMID: 10716986 Free PMC article.

5

Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates.

Kerr KM, Sauna ZE, Ambudkar SV. Kerr KM, et al. Among authors: sauna ze. J Biol Chem. 2001 Mar 23;276(12):8657-64. doi: 10.1074/jbc.M010044200. Epub 2000 Dec 19. J Biol Chem. 2001. PMID: 11121420 Free article.

6

Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes.

Sauna ZE, Ambudkar SV. Sauna ZE, et al. J Biol Chem. 2001 Apr 13;276(15):11653-61. doi: 10.1074/jbc.M011294200. Epub 2001 Jan 11. J Biol Chem. 2001. PMID: 11154703 Free article.

7

Sauna ZE, Smith MM, Muller M, Ambudkar SV. Sauna ZE, et al. J Biol Chem. 2001 Jun 15;276(24):21199-208. doi: 10.1074/jbc.M100886200. Epub 2001 Apr 3. J Biol Chem. 2001. PMID: 11287418 Free article.

8

Evidence for the vectorial nature of drug (substrate)-stimulated ATP hydrolysis by human P-glycoprotein.

Sauna ZE, Smith MM, Müller M, Ambudkar SV. Sauna ZE, et al. J Biol Chem. 2001 Sep 7;276(36):33301-4. doi: 10.1074/jbc.C100369200. Epub 2001 Jul 12. J Biol Chem. 2001. PMID: 11451943 Free article.

9

P-glycoprotein: from genomics to mechanism.

Ambudkar SV, Kimchi-Sarfaty C, Sauna ZE, Gottesman MM. Ambudkar SV, et al. Among authors: sauna ze. Oncogene. 2003 Oct 20;22(47):7468-85. doi: 10.1038/sj.onc.1206948. Oncogene. 2003. PMID: 14576852 Review.

10

The power of the pump: mechanisms of action of P-glycoprotein (ABCB1).

Ambudkar SV, Kim IW, Sauna ZE. Ambudkar SV, et al. Among authors: sauna ze. Eur J Pharm Sci. 2006 Apr;27(5):392-400. doi: 10.1016/j.ejps.2005.10.010. Epub 2005 Dec 13. Eur J Pharm Sci. 2006. PMID: 16352426 Review.

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