Neckers L - Search Results

1

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90.

Xu W, Mimnaugh E, Rosser MF, Nicchitta C, Marcu M, Yarden Y, Neckers L. Xu W, et al. Among authors: neckers l. J Biol Chem. 2001 Feb 2;276(5):3702-8. doi: 10.1074/jbc.M006864200. Epub 2000 Nov 8. J Biol Chem. 2001. PMID: 11071886 Free article.

2

Heikkila R, Trepel JB, Cuttitta F, Neckers LM, Sausville EA. Heikkila R, et al. Among authors: neckers lm. J Biol Chem. 1987 Dec 5;262(34):16456-60. J Biol Chem. 1987. PMID: 2824495 Free article.

3

Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase.

Mimnaugh EG, Worland PJ, Whitesell L, Neckers LM. Mimnaugh EG, et al. Among authors: neckers lm. J Biol Chem. 1995 Dec 1;270(48):28654-9. doi: 10.1074/jbc.270.48.28654. J Biol Chem. 1995. PMID: 7499384 Free article.

4

Taxol induction of p21WAF1 and p53 requires c-raf-1.

Blagosklonny MV, Schulte TW, Nguyen P, Mimnaugh EG, Trepel J, Neckers L. Blagosklonny MV, et al. Among authors: neckers l. Cancer Res. 1995 Oct 15;55(20):4623-6. Cancer Res. 1995. PMID: 7553639

5

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association.

Schulte TW, Blagosklonny MV, Ingui C, Neckers L. Schulte TW, et al. Among authors: neckers l. J Biol Chem. 1995 Oct 13;270(41):24585-8. doi: 10.1074/jbc.270.41.24585. J Biol Chem. 1995. PMID: 7592678 Free article.

6

Geldanamycin selectively destabilizes and conformationally alters mutated p53.

Blagosklonny MV, Toretsky J, Neckers L. Blagosklonny MV, et al. Among authors: neckers l. Oncogene. 1995 Sep 7;11(5):933-9. Oncogene. 1995. PMID: 7675452

7

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. Whitesell L, et al. Among authors: neckers lm. Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8324-8. doi: 10.1073/pnas.91.18.8324. Proc Natl Acad Sci U S A. 1994. PMID: 8078881 Free PMC article.

8

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

Chavany C, Mimnaugh E, Miller P, Bitton R, Nguyen P, Trepel J, Whitesell L, Schnur R, Moyer J, Neckers L. Chavany C, et al. Among authors: neckers l. J Biol Chem. 1996 Mar 1;271(9):4974-7. doi: 10.1074/jbc.271.9.4974. J Biol Chem. 1996. PMID: 8617772 Free article.

9

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

Blagosklonny MV, Toretsky J, Bohen S, Neckers L. Blagosklonny MV, et al. Among authors: neckers l. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8379-83. doi: 10.1073/pnas.93.16.8379. Proc Natl Acad Sci U S A. 1996. PMID: 8710879 Free PMC article.

10

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin.

Mimnaugh EG, Chavany C, Neckers L. Mimnaugh EG, et al. Among authors: neckers l. J Biol Chem. 1996 Sep 13;271(37):22796-801. doi: 10.1074/jbc.271.37.22796. J Biol Chem. 1996. PMID: 8798456 Free article.

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