Hirst WD - Search Results

1

The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.

Wood MD, Murkitt KL, Rice SQ, Testa T, Punia PK, Stammers M, Jenkins O, Elshourbagy NA, Shabon U, Taylor SJ, Gager TL, Minton J, Hirst WD, Price GW, Pangalos M. Wood MD, et al. Among authors: hirst wd. Br J Pharmacol. 2000 Nov;131(6):1050-4. doi: 10.1038/sj.bjp.0703682. Br J Pharmacol. 2000. PMID: 11082110 Free PMC article.

2

Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits.

Hirst WD, Babbs AJ, Green A, Minton JA, Shaw TE, Wise A, Rice SQ, Pangalos MN, Price GW. Hirst WD, et al. Biochem Pharmacol. 2003 Apr 1;65(7):1103-13. doi: 10.1016/s0006-2952(02)01658-1. Biochem Pharmacol. 2003. PMID: 12663046

3

Characterization of [(125)I]-SB-258585 binding to human recombinant and native 5-HT(6) receptors in rat, pig and human brain tissue.

Hirst WD, Minton JA, Bromidge SM, Moss SF, Latter AJ, Riley G, Routledge C, Middlemiss DN, Price GW. Hirst WD, et al. Br J Pharmacol. 2000 Aug;130(7):1597-605. doi: 10.1038/sj.bjp.0703458. Br J Pharmacol. 2000. PMID: 10928963 Free PMC article.

4

The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling.

Calver AR, Robbins MJ, Cosio C, Rice SQ, Babbs AJ, Hirst WD, Boyfield I, Wood MD, Russell RB, Price GW, Couve A, Moss SJ, Pangalos MN. Calver AR, et al. Among authors: hirst wd. J Neurosci. 2001 Feb 15;21(4):1203-10. doi: 10.1523/JNEUROSCI.21-04-01203.2001. J Neurosci. 2001. PMID: 11160390 Free PMC article.

5

Molecular and pharmacological characterization of a functional tachykinin NK3 receptor cloned from the rabbit iris sphincter muscle.

Medhurst AD, Hirst WD, Jerman JC, Meakin J, Roberts JC, Testa T, Smart D. Medhurst AD, et al. Among authors: hirst wd. Br J Pharmacol. 1999 Oct;128(3):627-36. doi: 10.1038/sj.bjp.0702854. Br J Pharmacol. 1999. PMID: 10516642 Free PMC article.

6

Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling.

Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD. Hirst WD, et al. Mol Pharmacol. 2003 Dec;64(6):1295-308. doi: 10.1124/mol.64.6.1295. Mol Pharmacol. 2003. PMID: 14645659

7

Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist.

Routledge C, Bromidge SM, Moss SF, Price GW, Hirst W, Newman H, Riley G, Gager T, Stean T, Upton N, Clarke SE, Brown AM, Middlemiss DN. Routledge C, et al. Br J Pharmacol. 2000 Aug;130(7):1606-12. doi: 10.1038/sj.bjp.0703457. Br J Pharmacol. 2000. PMID: 10928964 Free PMC article.

8

Identification of 5-hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes.

Hirst WD, Price GW, Rattray M, Wilkin GP. Hirst WD, et al. Br J Pharmacol. 1997 Feb;120(3):509-15. doi: 10.1038/sj.bjp.0700921. Br J Pharmacol. 1997. PMID: 9031757 Free PMC article.

9

Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor.

Langmead CJ, Szekeres PG, Chambers JK, Ratcliffe SJ, Jones DN, Hirst WD, Price GW, Herdon HJ. Langmead CJ, et al. Among authors: hirst wd. Br J Pharmacol. 2000 Oct;131(4):683-8. doi: 10.1038/sj.bjp.0703617. Br J Pharmacol. 2000. PMID: 11030716 Free PMC article.

10

GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.

Robbins MJ, Calver AR, Filippov AK, Hirst WD, Russell RB, Wood MD, Nasir S, Couve A, Brown DA, Moss SJ, Pangalos MN. Robbins MJ, et al. Among authors: hirst wd. J Neurosci. 2001 Oct 15;21(20):8043-52. doi: 10.1523/JNEUROSCI.21-20-08043.2001. J Neurosci. 2001. PMID: 11588177 Free PMC article.

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