Usherwood PN - Search Results

1

Location of the polyamine binding site in the vestibule of the nicotinic acetylcholine receptor ion channel.

Bixel MG, Weise C, Bolognesi ML, Rosini M, Brierly MJ, Mellor IR, Usherwood PN, Melchiorre C, Hucho F. Bixel MG, et al. Among authors: usherwood pn. J Biol Chem. 2001 Mar 2;276(9):6151-60. doi: 10.1074/jbc.M008467200. Epub 2000 Dec 4. J Biol Chem. 2001. PMID: 11104766 Free article.

2

Structure-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor.

Bixel MG, Krauss M, Liu Y, Bolognesi ML, Rosini M, Mellor IS, Usherwood PN, Melchiorre C, Nakanishi K, Hucho F. Bixel MG, et al. Among authors: usherwood pn. Eur J Biochem. 2000 Jan;267(1):110-20. doi: 10.1046/j.1432-1327.2000.00971.x. Eur J Biochem. 2000. PMID: 10601857 Free article.

3

Binding of polyamine-containing toxins in the vestibule of the nicotinic acetylcholine receptor ion channel.

Bixel MG, Krauss M, Weise C, Bolognesi ML, Rosini M, Usherwood PN, Melchiorre C, Hucho F. Bixel MG, et al. Among authors: usherwood pn. Farmaco. 2001 Jan-Feb;56(1-2):133-5. doi: 10.1016/s0014-827x(01)01012-6. Farmaco. 2001. PMID: 11347955

4

Modeling noncompetitive antagonism of a nicotinic acetylcholine receptor.

Tikhonov DB, Mellor IR, Usherwood PN. Tikhonov DB, et al. Among authors: usherwood pn. Biophys J. 2004 Jul;87(1):159-70. doi: 10.1529/biophysj.103.037457. Biophys J. 2004. PMID: 15240454 Free PMC article.

5

Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists.

Rosini M, Budriesi R, Bixel MG, Bolognesi ML, Chiarini A, Hucho F, Krogsgaard-Larsen P, Mellor IR, Minarini A, Tumiatti V, Usherwood PN, Melchiorre C. Rosini M, et al. Among authors: usherwood pn. J Med Chem. 1999 Dec 16;42(25):5212-23. doi: 10.1021/jm991110n. J Med Chem. 1999. PMID: 10602706

6

Targeting ionotropic receptors with polyamine-containing toxins.

Mellor IR, Usherwood PN. Mellor IR, et al. Among authors: usherwood pn. Toxicon. 2004 Apr;43(5):493-508. doi: 10.1016/j.toxicon.2004.02.003. Toxicon. 2004. PMID: 15066409 Review.

7

Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor.

Stromgaard K, Brierley MJ, Andersen K, Sløk FA, Mellor IR, Usherwood PN, Krogsgaard-Larsen P, Jaroszewski JW. Stromgaard K, et al. Among authors: usherwood pn. J Med Chem. 1999 Dec 16;42(25):5224-34. doi: 10.1021/jm9903747. J Med Chem. 1999. PMID: 10602707

8

Functional expression of a recombinant unitary glutamate receptor from Xenopus, which contains N-methyl-D-aspartate (NMDA) and non-NMDA receptor subunits.

Soloviev MM, Brierley MJ, Shao ZY, Mellor IR, Volkova TM, Kamboj R, Ishimaru H, Sudan H, Harris J, Foldes RL, Grishin EV, Usherwood PN, Barnard EA. Soloviev MM, et al. Among authors: usherwood pn. J Biol Chem. 1996 Dec 20;271(51):32572-9. doi: 10.1074/jbc.271.51.32572. J Biol Chem. 1996. PMID: 8955083 Free article.

9

Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist.

Strømgaard K, Mellor IR, Andersen K, Neagoe I, Pluteanu F, Usherwood PN, Krogsgaard-Larsen P, Jaroszewski JW. Strømgaard K, et al. Among authors: usherwood pn. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1159-62. doi: 10.1016/s0960-894x(02)00120-8. Bioorg Med Chem Lett. 2002. PMID: 11934578

10

The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism.

Jørgensen MR, Olsen CA, Mellor IR, Usherwood PN, Witt M, Franzyk H, Jaroszewski JW. Jørgensen MR, et al. Among authors: usherwood pn. J Med Chem. 2005 Jan 13;48(1):56-70. doi: 10.1021/jm049906w. J Med Chem. 2005. PMID: 15634001

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