Roepe PD - Search Results

1

Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena.

Ursos LM, DuBay KF, Roepe PD. Ursos LM, et al. Among authors: roepe pd. Mol Biochem Parasitol. 2001 Jan 15;112(1):11-7. doi: 10.1016/s0166-6851(00)00342-x. Mol Biochem Parasitol. 2001. PMID: 11166382

Recently, we measured a more acid digestive vacuolar pH for drug resistant Plasmodium falciparum [Dzekunov S, Ursos LMB, Roepe PD. Mol Biochem Parasitol 2000;in press; Ursos LMB, Dzekunov S, Roepe PD. Mol Biochem Parasitol 2000;in press]. ...These data …

Recently, we measured a more acid digestive vacuolar pH for drug resistant Plasmodium falciparum [Dzekunov S, Ursos LMB, Roepe PD …

2

Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine.

Dzekunov SM, Ursos LM, Roepe PD. Dzekunov SM, et al. Among authors: roepe pd. Mol Biochem Parasitol. 2000 Sep;110(1):107-24. doi: 10.1016/s0166-6851(00)00261-9. Mol Biochem Parasitol. 2000. PMID: 10989149

3

The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive or resistant to chloroquine.

Ursos LM, Dzekunov SM, Roepe PD. Ursos LM, et al. Among authors: roepe pd. Mol Biochem Parasitol. 2000 Sep;110(1):125-34. doi: 10.1016/s0166-6851(00)00262-0. Mol Biochem Parasitol. 2000. PMID: 10989150

4

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.

Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LM, Sidhu AB, Naudé B, Deitsch KW, Su XZ, Wootton JC, Roepe PD, Wellems TE. Fidock DA, et al. Among authors: roepe pd. Mol Cell. 2000 Oct;6(4):861-71. doi: 10.1016/s1097-2765(05)00077-8. Mol Cell. 2000. PMID: 11090624 Free PMC article.

5

Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America.

Mehlotra RK, Fujioka H, Roepe PD, Janneh O, Ursos LM, Jacobs-Lorena V, McNamara DT, Bockarie MJ, Kazura JW, Kyle DE, Fidock DA, Zimmerman PA. Mehlotra RK, et al. Among authors: roepe pd. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12689-94. doi: 10.1073/pnas.221440898. Proc Natl Acad Sci U S A. 2001. PMID: 11675500 Free PMC article.

6

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.

Cooper RA, Ferdig MT, Su XZ, Ursos LM, Mu J, Nomura T, Fujioka H, Fidock DA, Roepe PD, Wellems TE. Cooper RA, et al. Among authors: roepe pd. Mol Pharmacol. 2002 Jan;61(1):35-42. doi: 10.1124/mol.61.1.35. Mol Pharmacol. 2002. PMID: 11752204

7

Solution structures of antimalarial drug-heme complexes.

Leed A, DuBay K, Ursos LM, Sears D, De Dios AC, Roepe PD. Leed A, et al. Among authors: roepe pd. Biochemistry. 2002 Aug 13;41(32):10245-55. doi: 10.1021/bi020195i. Biochemistry. 2002. PMID: 12162739

8

Chloroquine resistance in the malarial parasite, Plasmodium falciparum.

Ursos LM, Roepe PD. Ursos LM, et al. Among authors: roepe pd. Med Res Rev. 2002 Sep;22(5):465-91. doi: 10.1002/med.10016. Med Res Rev. 2002. PMID: 12210555 Review.

9

Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter.

Waller KL, Muhle RA, Ursos LM, Horrocks P, Verdier-Pinard D, Sidhu AB, Fujioka H, Roepe PD, Fidock DA. Waller KL, et al. Among authors: roepe pd. J Biol Chem. 2003 Aug 29;278(35):33593-601. doi: 10.1074/jbc.M302215200. Epub 2003 Jun 17. J Biol Chem. 2003. PMID: 12813054 Free article.

10

Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.

Bennett TN, Kosar AD, Ursos LM, Dzekunov S, Singh Sidhu AB, Fidock DA, Roepe PD. Bennett TN, et al. Among authors: roepe pd. Mol Biochem Parasitol. 2004 Jan;133(1):99-114. doi: 10.1016/j.molbiopara.2003.09.008. Mol Biochem Parasitol. 2004. PMID: 14668017

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