Laughton CA - Search Results

1

Evaluation of the mechanism of aromatase cytochrome P450. A site-directed mutagenesis study.

Kao YC, Korzekwa KR, Laughton CA, Chen S. Kao YC, et al. Among authors: laughton ca. Eur J Biochem. 2001 Jan;268(2):243-51. doi: 10.1046/j.1432-1033.2001.01886.x. Eur J Biochem. 2001. PMID: 11168357 Free article.

2

Binding characteristics of aromatase inhibitors and phytoestrogens to human aromatase.

Chen S, Kao YC, Laughton CA. Chen S, et al. Among authors: laughton ca. J Steroid Biochem Mol Biol. 1997 Apr;61(3-6):107-15. J Steroid Biochem Mol Biol. 1997. PMID: 9365179

3

Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.

Kao YC, Zhou C, Sherman M, Laughton CA, Chen S. Kao YC, et al. Among authors: laughton ca. Environ Health Perspect. 1998 Feb;106(2):85-92. doi: 10.1289/ehp.9810685. Environ Health Perspect. 1998. PMID: 9435150 Free PMC article.

4

Mutagenesis study at a postulated hydrophobic region near the active site of aromatase cytochrome P450.

Zhou D, Cam LL, Laughton CA, Korzekwa KR, Chen S. Zhou D, et al. Among authors: laughton ca. J Biol Chem. 1994 Jul 29;269(30):19501-8. J Biol Chem. 1994. PMID: 8034720 Free article.

5

Binding characteristics of seven inhibitors of human aromatase: a site-directed mutagenesis study.

Kao YC, Cam LL, Laughton CA, Zhou D, Chen S. Kao YC, et al. Among authors: laughton ca. Cancer Res. 1996 Aug 1;56(15):3451-60. Cancer Res. 1996. PMID: 8758911

6

Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate.

Cody V, Chan D, Galitsky N, Rak D, Luft JR, Pangborn W, Queener SF, Laughton CA, Stevens MF. Cody V, et al. Among authors: laughton ca. Biochemistry. 2000 Apr 4;39(13):3556-64. doi: 10.1021/bi9924563. Biochemistry. 2000. PMID: 10736154

7

A detailed molecular model for human aromatase.

Laughton CA, Zvelebil MJ, Neidle S. Laughton CA, et al. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):399-407. doi: 10.1016/0960-0760(93)90243-p. J Steroid Biochem Mol Biol. 1993. PMID: 8476753

8

Homology modelling of the enzyme P450 17 alpha-hydroxylase/17,20-lyase--a target for prostate cancer chemotherapy--from the crystal structure of P450BM-3.

Burke DF, Laughton CA, Neidle S. Burke DF, et al. Among authors: laughton ca. Anticancer Drug Des. 1997 Mar;12(2):113-23. Anticancer Drug Des. 1997. PMID: 9113066

9

Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives.

Laughton CA, McKenna R, Neidle S, Jarman M, McCague R, Rowlands MG. Laughton CA, et al. J Med Chem. 1990 Sep;33(9):2673-9. doi: 10.1021/jm00171a052. J Med Chem. 1990. PMID: 2391706

10

Enantioselectivity of some 1-[(benzofuran-2-yl) phenylmethyl] imidazoles as aromatase (P450AROM) inhibitors.

Khodarahmi GA, Laughton CA, Smith HJ, Nicholls PJ. Khodarahmi GA, et al. Among authors: laughton ca. J Enzyme Inhib. 2001 Nov;16(5):401-16. doi: 10.1080/14756360109162389. J Enzyme Inhib. 2001. PMID: 11916146

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