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Page 1
2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor.
Harada H, Asano O, Hoshino Y, Yoshikawa S, Matsukura M, Kabasawa Y, Niijima J, Kotake Y, Watanabe N, Kawata T, Inoue T, Horizoe T, Yasuda N, Minami H, Nagata K, Murakami M, Nagaoka J, Kobayashi S, Tanaka I, Abe S. Harada H, et al. Among authors: asano o. J Med Chem. 2001 Jan 18;44(2):170-9. doi: 10.1021/jm990499b. J Med Chem. 2001. PMID: 11170626
Inhibitory effects of the novel platelet activating factor receptor antagonist, 1-ethyl-2-[N-(2-methoxy)benzoyl-N-[(2R)-2-methoxy-3-(4- octadecylcarbamoyloxy) piperidinocarbonyloxypropyloxy]carbonyl] aminomethyl-pyridinium chloride, in several experimentally induced shock models.
Nagaoka J, Harada K, Kimura A, Kobayashi S, Murakami M, Yoshimura T, Yamada K, Asano O, Katayama K, Yamatsu I. Nagaoka J, et al. Among authors: asano o. Arzneimittelforschung. 1991 Jul;41(7):719-24. Arzneimittelforschung. 1991. PMID: 1663352
Anti-endotoxin activity of a novel synthetic lipid A analog.
Kawata T, Bristol JR, Rose JR, Rossignol DP, Christ WJ, Asano O, Dubuc GR, Gavin WE, Hawkins LD, Kishi Y, et al. Kawata T, et al. Among authors: asano o. Prog Clin Biol Res. 1995;392:499-509. Prog Clin Biol Res. 1995. PMID: 8524958
2-Alkynyl-8-aryladenines possessing an amide moiety: their synthesis and structure-activity relationships of effects on hepatic glucose production induced via agonism of the A(2B) adenosine receptor.
Harada H, Asano O, Kawata T, Inoue T, Horizoe T, Yasuda N, Nagata K, Murakami M, Nagaoka J, Kobayashi S, Tanaka I, Abe S. Harada H, et al. Among authors: asano o. Bioorg Med Chem. 2001 Oct;9(10):2709-26. doi: 10.1016/s0968-0896(01)00201-2. Bioorg Med Chem. 2001. PMID: 11557358
E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor.
Yasuda N, Nagakura T, Inoue T, Yamazaki K, Katsutani N, Takenaka O, Clark R, Matsuura F, Emori E, Yoshikawa S, Kira K, Ikuta H, Okada T, Saeki T, Asano O, Tanaka I. Yasuda N, et al. Among authors: asano o. Eur J Pharmacol. 2006 Oct 24;548(1-3):181-7. doi: 10.1016/j.ejphar.2006.08.011. Epub 2006 Aug 16. Eur J Pharmacol. 2006. PMID: 16973152
Ten-Gram-Scale Total Synthesis of the Anticancer Drug Candidate E7130 to Supply Clinical Trials.
Kaburagi Y, Kira K, Yahata K, Iso K, Sato Y, Matsuura F, Ohashi I, Matsumoto Y, Isomura M, Sasaki T, Fukuyama T, Miyashita Y, Azuma H, Iida D, Ishida T, Itano W, Matsuda M, Matsukura M, Murai N, Nagao S, Seki M, Yamamoto A, Yamamoto Y, Yoneda N, Watanabe Y, Kamada A, Kayano A, Tagami K, Asano O, Owa T, Kishi Y. Kaburagi Y, et al. Among authors: asano o. Org Lett. 2024 Apr 12;26(14):2837-2842. doi: 10.1021/acs.orglett.3c03663. Epub 2024 Jan 22. Org Lett. 2024. PMID: 38252895
21 results