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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George Hyslop P, Selkoe DJ. Citron M, et al. Among authors: seubert p. Nat Med. 1997 Jan;3(1):67-72. doi: 10.1038/nm0197-67. Nat Med. 1997. PMID: 8986743
A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes.
Gómez-Isla T, Wasco W, Pettingell WP, Gurubhagavatula S, Schmidt SD, Jondro PD, McNamara M, Rodes LA, DiBlasi T, Growdon WB, Seubert P, Schenk D, Growdon JH, Hyman BT, Tanzi RE. Gómez-Isla T, et al. Among authors: seubert p. Ann Neurol. 1997 Jun;41(6):809-13. doi: 10.1002/ana.410410618. Ann Neurol. 1997. PMID: 9189043
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P. Schenk D, et al. Among authors: seubert p. Nature. 1999 Jul 8;400(6740):173-7. doi: 10.1038/22124. Nature. 1999. PMID: 10408445
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease.
Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Seubert P, Schenk D, Yednock T. Bard F, et al. Among authors: seubert p. Nat Med. 2000 Aug;6(8):916-9. doi: 10.1038/78682. Nat Med. 2000. PMID: 10932230
Current progress in beta-amyloid immunotherapy.
Schenk D, Hagen M, Seubert P. Schenk D, et al. Among authors: seubert p. Curr Opin Immunol. 2004 Oct;16(5):599-606. doi: 10.1016/j.coi.2004.07.012. Curr Opin Immunol. 2004. PMID: 15342006 Review.
Immunotherapy reduces vascular amyloid-beta in PDAPP mice.
Schroeter S, Khan K, Barbour R, Doan M, Chen M, Guido T, Gill D, Basi G, Schenk D, Seubert P, Games D. Schroeter S, et al. Among authors: seubert p. J Neurosci. 2008 Jul 2;28(27):6787-93. doi: 10.1523/JNEUROSCI.2377-07.2008. J Neurosci. 2008. PMID: 18596154 Free PMC article.
98 results