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A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug.
Mayer A, Francis RJ, Sharma SK, Tolner B, Springer CJ, Martin J, Boxer GM, Bell J, Green AJ, Hartley JA, Cruickshank C, Wren J, Chester KA, Begent RH. Mayer A, et al. Among authors: tolner b. Clin Cancer Res. 2006 Nov 1;12(21):6509-16. doi: 10.1158/1078-0432.CCR-06-0769. Clin Cancer Res. 2006. PMID: 17085666 Clinical Trial.
Engineering a single-chain Fv antibody to alpha v beta 6 integrin using the specificity-determining loop of a foot-and-mouth disease virus.
Kogelberg H, Tolner B, Thomas GJ, Di Cara D, Minogue S, Ramesh B, Sodha S, Marsh D, Lowdell MW, Meyer T, Begent RH, Hart I, Marshall JF, Chester K. Kogelberg H, et al. Among authors: tolner b. J Mol Biol. 2008 Oct 3;382(2):385-401. doi: 10.1016/j.jmb.2008.07.013. Epub 2008 Jul 16. J Mol Biol. 2008. PMID: 18656482 Free PMC article.
Generation and characterization of a diabody targeting the αvβ6 integrin.
Kogelberg H, Miranda E, Burnet J, Ellison D, Tolner B, Foster J, Picón C, Thomas GJ, Meyer T, Marshall JF, Mather SJ, Chester K. Kogelberg H, et al. Among authors: tolner b. PLoS One. 2013 Sep 4;8(9):e73260. doi: 10.1371/journal.pone.0073260. eCollection 2013. PLoS One. 2013. PMID: 24023846 Free PMC article.
Engineering antibodies for clinical applications in cancer.
Chester K, Pedley B, Tolner B, Violet J, Mayer A, Sharma S, Boxer G, Green A, Nagl S, Begent R. Chester K, et al. Among authors: tolner b. Tumour Biol. 2004 Jan-Apr;25(1-2):91-8. doi: 10.1159/000077727. Tumour Biol. 2004. PMID: 15192316 Review.
43 results