Christ DD - Search Results

1

Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor efavirenz.

Markwalder JA, Christ DD, Mutlib A, Cordova BC, Klabe RM, Seitz SP. Markwalder JA, et al. Among authors: christ dd. Bioorg Med Chem Lett. 2001 Mar 12;11(5):619-22. doi: 10.1016/s0960-894x(01)00012-9. Bioorg Med Chem Lett. 2001. PMID: 11266155

2

Liquid chromatography/mass spectrometry and high-field nuclear magnetic resonance characterization of novel mixed diconjugates of the non-nucleoside human immunodeficiency virus-1 reverse transcriptase inhibitor, efavirenz.

Mutlib AE, Chen H, Nemeth G, Gan LS, Christ DD. Mutlib AE, et al. Among authors: christ dd. Drug Metab Dispos. 1999 Sep;27(9):1045-56. Drug Metab Dispos. 1999. PMID: 10460805

3

Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz.

Mutlib AE, Chen H, Nemeth GA, Markwalder JA, Seitz SP, Gan LS, Christ DD. Mutlib AE, et al. Among authors: christ dd. Drug Metab Dispos. 1999 Nov;27(11):1319-33. Drug Metab Dispos. 1999. PMID: 10534318

4

The species-dependent metabolism of efavirenz produces a nephrotoxic glutathione conjugate in rats.

Mutlib AE, Gerson RJ, Meunier PC, Haley PJ, Chen H, Gan LS, Davies MH, Gemzik B, Christ DD, Krahn DF, Markwalder JA, Seitz SP, Robertson RT, Miwa GT. Mutlib AE, et al. Among authors: christ dd. Toxicol Appl Pharmacol. 2000 Nov 15;169(1):102-13. doi: 10.1006/taap.2000.9055. Toxicol Appl Pharmacol. 2000. PMID: 11076702

5

Mass spectrometric and NMR characterization of metabolites of roxifiban, a potent and selective antagonist of the platelet glycoprotein IIb/IIIa receptor.

Mutlib AE, Diamond S, Shockcor J, Way R, Nemeth G, Gan L, Christ DD. Mutlib AE, et al. Among authors: christ dd. Xenobiotica. 2000 Nov;30(11):1091-110. doi: 10.1080/00498250010006591. Xenobiotica. 2000. PMID: 11197070

6

Species-specific, P450- and sulfotransferase-mediated novel ring contraction of a naphthyridine-N-oxide compound in cynomolgus monkey.

Daniels JS, Espina R, Cao K, Yuan H, Lin J, Diamond S, Johnson B, Rodgers J, Prakash S, Unger S, Christ D, Miwa G, Gan LS, Mutlib A. Daniels JS, et al. Chem Res Toxicol. 2007 Nov;20(11):1709-17. doi: 10.1021/tx700170q. Epub 2007 Oct 17. Chem Res Toxicol. 2007. PMID: 17939741

7

Potent P1' biphenylmethyl substituted aggrecanase inhibitors.

Yao W, Chao M, Wasserman ZR, Liu RQ, Covington MB, Newton R, Christ D, Wexler RR, Decicco CP. Yao W, et al. Bioorg Med Chem Lett. 2002 Jan 7;12(1):101-4. doi: 10.1016/s0960-894x(01)00704-1. Bioorg Med Chem Lett. 2002. PMID: 11738583

8

The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1 ,5-a]-pyrimidine: a corticotropin-releasing factor (hCRF1) antagonist.

Gilligan PJ, Baldauf C, Cocuzza A, Chidester D, Zaczek R, Fitzgerald LW, McElroy J, Smith MA, Shen HS, Saye JA, Christ D, Trainor G, Robertson DW, Hartig P. Gilligan PJ, et al. Bioorg Med Chem. 2000 Jan;8(1):181-9. doi: 10.1016/s0968-0896(99)00271-0. Bioorg Med Chem. 2000. PMID: 10968277

9

4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2, 4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: a potent, orally bioavailable CRF(1) receptor antagonist.

He L, Gilligan PJ, Zaczek R, Fitzgerald LW, McElroy J, Shen HS, Saye JA, Kalin NH, Shelton S, Christ D, Trainor G, Hartig P. He L, et al. J Med Chem. 2000 Feb 10;43(3):449-56. doi: 10.1021/jm9904351. J Med Chem. 2000. PMID: 10669572

10

Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.

Yao W, Wasserman ZR, Chao M, Reddy G, Shi E, Liu RQ, Covington MB, Arner EC, Pratta MA, Tortorella M, Magolda RL, Newton R, Qian M, Ribadeneira MD, Christ D, Wexler RR, Decicco CP. Yao W, et al. J Med Chem. 2001 Oct 11;44(21):3347-50. doi: 10.1021/jm015533c. J Med Chem. 2001. PMID: 11585439

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