Natchus MG - Search Results

1

Chemoenzymatic synthesis of functionalized cyclohexylglycines and alpha-methylcyclohexylglycines via Kazmaier-Claisen rearrangement.

Hudlicky T, Oppong K, Duan C, Stanton C, Laufersweiler MJ, Natchus MG. Hudlicky T, et al. Among authors: natchus mg. Bioorg Med Chem Lett. 2001 Mar 12;11(5):627-9. doi: 10.1016/s0960-894x(01)00013-0. Bioorg Med Chem Lett. 2001. PMID: 11266157

2

Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold.

Cheng M, De B, Almstead NG, Pikul S, Dowty ME, Dietsch CR, Dunaway CM, Gu F, Hsieh LC, Janusz MJ, Taiwo YO, Natchus MG, Hudlicky T, Mandel M. Cheng M, et al. Among authors: natchus mg. J Med Chem. 1999 Dec 30;42(26):5426-36. doi: 10.1021/jm9904699. J Med Chem. 1999. PMID: 10639284

3

Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.

Natchus MG, Bookland RG, Laufersweiler MJ, Pikul S, Almstead NG, De B, Janusz MJ, Hsieh LC, Gu F, Pokross ME, Patel VS, Garver SM, Peng SX, Branch TM, King SL, Baker TR, Foltz DJ, Mieling GE. Natchus MG, et al. J Med Chem. 2001 Mar 29;44(7):1060-71. doi: 10.1021/jm000477l. J Med Chem. 2001. PMID: 11297453

4

The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold.

Tullis JS, Laufersweiler MJ, VanRens JC, Natchus MG, Bookland RG, Almstead NG, Pikul S, De B, Hsieh LC, Janusz MJ, Branch TM, Peng SX, Jin YY, Hudlicky T, Oppong K. Tullis JS, et al. Among authors: natchus mg. Bioorg Med Chem Lett. 2001 Aug 6;11(15):1975-9. doi: 10.1016/s0960-894x(01)00371-7. Bioorg Med Chem Lett. 2001. PMID: 11454461

5

Development of orally bioavailable bicyclic pyrazolones as inhibitors of tumor necrosis factor-alpha production.

Clark MP, Laughlin SK, Laufersweiler MJ, Bookland RG, Brugel TA, Golebiowski A, Sabat MP, Townes JA, VanRens JC, Djung JF, Natchus MG, De B, Hsieh LC, Xu SC, Walter RL, Mekel MJ, Heitmeyer SA, Brown KK, Juergens K, Taiwo YO, Janusz MJ. Clark MP, et al. Among authors: natchus mg. J Med Chem. 2004 May 20;47(11):2724-7. doi: 10.1021/jm049968m. J Med Chem. 2004. PMID: 15139749

6

Discovery of potent, achiral matrix metalloproteinase inhibitors.

Pikul S, McDow Dunham KL, Almstead NG, De B, Natchus MG, Anastasio MV, McPhail SJ, Snider CE, Taiwo YO, Rydel T, Dunaway CM, Gu F, Mieling GE. Pikul S, et al. Among authors: natchus mg. J Med Chem. 1998 Sep 10;41(19):3568-71. doi: 10.1021/jm980253r. J Med Chem. 1998. PMID: 9733482 No abstract available.

7

Design and synthesis of conformationally-constrained MMP inhibitors.

Natchus MG, Cheng M, Wahl CT, Pikul S, Almstead NG, Bradley RS, Taiwo YO, Mieling GE, Dunaway CM, Snider CE, McIver JM, Barnett BL, McPhail SJ, Anastasio MB, De B. Natchus MG, et al. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2077-80. doi: 10.1016/s0960-894x(98)00370-9. Bioorg Med Chem Lett. 1998. PMID: 9873489

8

Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases.

Pikul S, McDow Dunham KL, Almstead NG, De B, Natchus MG, Anastasio MV, McPhail SJ, Snider CE, Taiwo YO, Chen L, Dunaway CM, Gu F, Mieling GE. Pikul S, et al. Among authors: natchus mg. J Med Chem. 1999 Jan 14;42(1):87-94. doi: 10.1021/jm980142s. J Med Chem. 1999. PMID: 9888835

9

Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors.

Almstead NG, Bradley RS, Pikul S, De B, Natchus MG, Taiwo YO, Gu F, Williams LE, Hynd BA, Janusz MJ, Dunaway CM, Mieling GE. Almstead NG, et al. Among authors: natchus mg. J Med Chem. 1999 Nov 4;42(22):4547-62. doi: 10.1021/jm990330y. J Med Chem. 1999. PMID: 10579818

10

Design and synthesis of piperazine-based matrix metalloproteinase inhibitors.

Cheng M, De B, Pikul S, Almstead NG, Natchus MG, Anastasio MV, McPhail SJ, Snider CE, Taiwo YO, Chen L, Dunaway CM, Gu F, Dowty ME, Mieling GE, Janusz MJ, Wang-Weigand S. Cheng M, et al. Among authors: natchus mg. J Med Chem. 2000 Feb 10;43(3):369-80. doi: 10.1021/jm990366q. J Med Chem. 2000. PMID: 10669564

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