Trimble LA - Search Results

1

In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.

Yergey JA, Trimble LA, Silva J, Chauret N, Li C, Therien M, Grimm E, Nicoll-Griffith DA. Yergey JA, et al. Among authors: trimble la. Drug Metab Dispos. 2001 May;29(5):638-44. Drug Metab Dispos. 2001. PMID: 11302928

2

Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560.

Bateman KP, Trimble L, Chauret N, Silva J, Day S, Macdonald D, Dube D, Gallant M, Mastracchio A, Perrier H, Girard Y, Nicoll-Griffith D. Bateman KP, et al. J Mass Spectrom. 2006 Jun;41(6):771-80. doi: 10.1002/jms.1033. J Mass Spectrom. 2006. PMID: 16705670

3

In vitro and in vivo biotransformations of the naphthalenic lignan lactone 5-lipoxygenase inhibitor, L-702,539.

Chauret N, Li C, Ducharme Y, Trimble LA, Yergey JA, Ramachandran C, Nicoll-Griffith DA. Chauret N, et al. Among authors: trimble la. Drug Metab Dispos. 1995 Jan;23(1):65-71. Drug Metab Dispos. 1995. PMID: 7720527

4

Characterization of verlukast metabolites arising from an epoxide intermediate produced with hepatic microsomes from beta-naphthoflavone-treated rodents (P-4501A1).

Nicoll-Griffith DA, Chauret N, Yergey JA, Trimble LA, Favreau L, Zamboni R, Grossman SJ, Drey J, Herold E. Nicoll-Griffith DA, et al. Among authors: trimble la. Drug Metab Dispos. 1993 Sep-Oct;21(5):861-7. Drug Metab Dispos. 1993. PMID: 7902249

5

Verlukast (MK-0679) conjugation with glutathione by rat liver and kidney cytosols and excretion in the bile.

Nicoll-Griffith DA, Gupta N, Twa SP, Williams H, Trimble LA, Yergey JA. Nicoll-Griffith DA, et al. Among authors: trimble la. Drug Metab Dispos. 1995 Oct;23(10):1085-93. Drug Metab Dispos. 1995. PMID: 8654196

6

Integrated application of capillary HPLC/continuous-flow liquid secondary ion mass spectrometry to discovery stage metabolism studies.

Li C, Chauret N, Ducharme Y, Trimble LA, Nicoll-Griffith DA, Yergey JA. Li C, et al. Among authors: trimble la. Anal Chem. 1995 Sep 1;67(17):2931-6. doi: 10.1021/ac00113a030. Anal Chem. 1995. PMID: 8779418

7

Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).

Nicoll-Griffith DA, Yergey JA, Trimble LA, Silva JM, Li C, Chauret N, Gauthier JY, Grimm E, Léger S, Roy P, Thérien M, Wang Z, Prasit P, Zamboni R, Young RN, Brideau C, Chan CC, Mancini J, Riendeau D. Nicoll-Griffith DA, et al. Among authors: trimble la. Bioorg Med Chem Lett. 2000 Dec 4;10(23):2683-6. doi: 10.1016/s0960-894x(00)00538-2. Bioorg Med Chem Lett. 2000. PMID: 11128651

8

Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization.

Li C, Chauret N, Trimble LA, Nicoll-Griffith DA, Silva JM, MacDonald D, Perrier H, Yergey JA, Parton T, Alexander RP, Warrellow GJ. Li C, et al. Among authors: trimble la. Drug Metab Dispos. 2001 Mar;29(3):232-41. Drug Metab Dispos. 2001. PMID: 11181489

9

In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).

Chauret N, Yergey JA, Brideau C, Friesen RW, Mancini J, Riendeau D, Silva J, Styhler A, Trimble LA, Nicoll-Griffith DA. Chauret N, et al. Among authors: trimble la. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1059-62. doi: 10.1016/s0960-894x(01)00135-4. Bioorg Med Chem Lett. 2001. PMID: 11327589

10

In vitro and in vivo biotransformations of the potent leukotriene D4 antagonist verlukast in the rat.

Nicoll-Griffith D, Yergey J, Trimble L, Williams H, Rasori R, Zamboni R. Nicoll-Griffith D, et al. Drug Metab Dispos. 1992 May-Jun;20(3):383-9. Drug Metab Dispos. 1992. PMID: 1355712

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

48 results

Search Page

Filters