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A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.
Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB. Ohm JE, et al. Among authors: watkins dn. Nat Genet. 2007 Feb;39(2):237-42. doi: 10.1038/ng1972. Epub 2007 Jan 9. Nat Genet. 2007. PMID: 17211412 Free PMC article.
Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice.
Mohammad HP, Zhang W, Prevas HS, Leadem BR, Zhang M, Herman JG, Hooker CM, Watkins DN, Karim B, Huso DL, Baylin SB. Mohammad HP, et al. Among authors: watkins dn. Oncogene. 2011 Jun 9;30(23):2659-69. doi: 10.1038/onc.2010.633. Epub 2011 Feb 7. Oncogene. 2011. PMID: 21297660 Free PMC article.
127 results