Denny WA - Search Results

1

Comparative biodistribution and metabolism of carbon-11-labeled N-[2-(dimethylamino)ethyl]acridine-4-carboxamide and DNA-intercalating analogues.

Osman S, Rowlinson-Busza G, Luthra SK, Aboagye EO, Brown GD, Brady F, Myers R, Gamage SA, Denny WA, Baguley BC, Price PM. Osman S, et al. Among authors: denny wa. Cancer Res. 2001 Apr 1;61(7):2935-44. Cancer Res. 2001. PMID: 11306471

2

Carbon-11 labelling of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and determination of plasma metabolites in man.

Brady F, Luthra SK, Brown G, Osman S, Harte RJ, Denny WA, Baguley BC, Jones T, Price PM. Brady F, et al. Among authors: denny wa. Appl Radiat Isot. 1997 Apr;48(4):487-92. doi: 10.1016/s0969-8043(96)00294-1. Appl Radiat Isot. 1997. PMID: 9106990 Clinical Trial.

3

Studies on the metabolism of the novel antitumor agent [N-methyl-11C]N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in rats and humans prior to phase I clinical trials.

Osman S, Luthra SK, Brady F, Hume SP, Brown G, Harte RJ, Matthews JC, Denny WA, Baguley BC, Jones T, Price PM. Osman S, et al. Among authors: denny wa. Cancer Res. 1997 Jun 1;57(11):2172-80. Cancer Res. 1997. PMID: 9187117 Clinical Trial.

4

Amsacrine analogues with extended chromophores: DNA binding and anti-tumour activity.

Denny WA, Baguley BC. Denny WA, et al. Anticancer Drug Des. 1987 Aug;2(1):61-70. Anticancer Drug Des. 1987. PMID: 3449085

5

'Minimal' DNA-intercalating agents as anti-tumour drugs: 2-styrylquinoline analogues of amsacrine.

Denny WA, Atwell GJ, Baguley BC. Denny WA, et al. Anticancer Drug Des. 1987 Dec;2(3):263-70. Anticancer Drug Des. 1987. PMID: 3449090

6

Electron-deficient DNA-intercalating agents as antitumor drugs: aza analogues of the experimental clinical agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.

Chen Q, Deady LW, Baguley BC, Denny WA. Chen Q, et al. Among authors: denny wa. J Med Chem. 1994 Mar 4;37(5):593-7. doi: 10.1021/jm00031a008. J Med Chem. 1994. PMID: 8126699

7

Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.

Spicer JA, Gamage SA, Atwell GJ, Finlay GJ, Baguley BC, Denny WA. Spicer JA, et al. Among authors: denny wa. J Med Chem. 1997 Jun 6;40(12):1919-29. doi: 10.1021/jm970004n. J Med Chem. 1997. PMID: 9191970

8

5,7-Disubstituted analogues of the mixed topoisomerase I/II poison N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA): DNA binding and patterns of cytotoxicity.

Spicer JA, Finlay GJ, Baguley BC, Velea L, Graves DE, Denny WA. Spicer JA, et al. Among authors: denny wa. Anticancer Drug Des. 1999 Feb;14(1):37-45. Anticancer Drug Des. 1999. PMID: 10363026

9

Cellular uptake of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA).

Haldane A, Finlay GJ, Hay MP, Denny WA, Baguley BC. Haldane A, et al. Among authors: denny wa. Anticancer Drug Des. 1999 Jun;14(3):275-80. Anticancer Drug Des. 1999. PMID: 10500502

10

Dimeric analogues of non-cationic tricyclic aromatic carboxamides are a new class of cytotoxic agents.

Spicer JA, Gamage SA, Atwell GJ, Finlay GJ, Baguley BC, Denny WA. Spicer JA, et al. Among authors: denny wa. Anticancer Drug Des. 1999 Jun;14(3):281-9. Anticancer Drug Des. 1999. PMID: 10500503

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