Leadlay PF - Search Results

1

Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates.

Holzbaur IE, Ranganathan A, Thomas IP, Kearney DJ, Reather JA, Rudd BA, Staunton J, Leadlay PF. Holzbaur IE, et al. Among authors: leadlay pf. Chem Biol. 2001 Apr;8(4):329-40. doi: 10.1016/s1074-5521(01)00014-x. Chem Biol. 2001. PMID: 11325589

2

Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer.

Thomas I, Martin CJ, Wilkinson CJ, Staunton J, Leadlay PF. Thomas I, et al. Among authors: leadlay pf. Chem Biol. 2002 Jul;9(7):781-7. doi: 10.1016/s1074-5521(02)00164-3. Chem Biol. 2002. PMID: 12144921

3

Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases.

Siskos AP, Baerga-Ortiz A, Bali S, Stein V, Mamdani H, Spiteller D, Popovic B, Spencer JB, Staunton J, Weissman KJ, Leadlay PF. Siskos AP, et al. Among authors: leadlay pf. Chem Biol. 2005 Oct;12(10):1145-53. doi: 10.1016/j.chembiol.2005.08.017. Chem Biol. 2005. PMID: 16242657

4

A hybrid modular polyketide synthase obtained by domain swapping.

Oliynyk M, Brown MJ, Cortés J, Staunton J, Leadlay PF. Oliynyk M, et al. Among authors: leadlay pf. Chem Biol. 1996 Oct;3(10):833-9. doi: 10.1016/s1074-5521(96)90069-1. Chem Biol. 1996. PMID: 8939702

5

Polyketide synthesis in vitro on a modular polyketide synthase.

Wiesmann KE, Cortés J, Brown MJ, Cutter AL, Staunton J, Leadlay PF. Wiesmann KE, et al. Among authors: leadlay pf. Chem Biol. 1995 Sep;2(9):583-9. doi: 10.1016/1074-5521(95)90122-1. Chem Biol. 1995. PMID: 9383462

6

Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension.

Böhm I, Holzbaur IE, Hanefeld U, Cortés J, Staunton J, Leadlay PF. Böhm I, et al. Among authors: leadlay pf. Chem Biol. 1998 Aug;5(8):407-12. doi: 10.1016/s1074-5521(98)90157-0. Chem Biol. 1998. PMID: 9710562

7

Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase.

Weissman KJ, Bycroft M, Cutter AL, Hanefeld U, Frost EJ, Timoney MC, Harris R, Handa S, Roddis M, Staunton J, Leadlay PF. Weissman KJ, et al. Among authors: leadlay pf. Chem Biol. 1998 Dec;5(12):743-54. doi: 10.1016/s1074-5521(98)90666-4. Chem Biol. 1998. PMID: 9862800

8

Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase.

Holzbaur IE, Harris RC, Bycroft M, Cortes J, Bisang C, Staunton J, Rudd BA, Leadlay PF. Holzbaur IE, et al. Among authors: leadlay pf. Chem Biol. 1999 Apr;6(4):189-95. doi: 10.1016/S1074-5521(99)80035-0. Chem Biol. 1999. PMID: 10099131

9

Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues.

Ranganathan A, Timoney M, Bycroft M, Cortés J, Thomas IP, Wilkinson B, Kellenberger L, Hanefeld U, Galloway IS, Staunton J, Leadlay PF. Ranganathan A, et al. Among authors: leadlay pf. Chem Biol. 1999 Oct;6(10):731-41. doi: 10.1016/s1074-5521(00)80020-4. Chem Biol. 1999. PMID: 10508677

10

Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase.

Wilkinson B, Foster G, Rudd BA, Taylor NL, Blackaby AP, Sidebottom PJ, Cooper DJ, Dawson MJ, Buss AD, Gaisser S, Böhm IU, Rowe CJ, Cortés J, Leadlay PF, Staunton J. Wilkinson B, et al. Among authors: leadlay pf. Chem Biol. 2000 Feb;7(2):111-7. doi: 10.1016/s1074-5521(00)00076-4. Chem Biol. 2000. PMID: 10662692

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