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Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis.
Kim BT, Kitagawa H, Tamura J, Saito T, Kusche-Gullberg M, Lindahl U, Sugahara K. Kim BT, et al. Among authors: sugahara k. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7176-81. doi: 10.1073/pnas.131188498. Epub 2001 Jun 5. Proc Natl Acad Sci U S A. 2001. PMID: 11390981 Free PMC article.
Heparin and heparan sulfate biosynthesis.
Sugahara K, Kitagawa H. Sugahara K, et al. IUBMB Life. 2002 Oct;54(4):163-75. doi: 10.1080/15216540214928. IUBMB Life. 2002. PMID: 12512855 Free article. Review.
Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.
Kitagawa H, Izumikawa T, Mizuguchi S, Dejima K, Nomura KH, Egusa N, Taniguchi F, Tamura J, Gengyo-Ando K, Mitani S, Nomura K, Sugahara K. Kitagawa H, et al. Among authors: sugahara k. J Biol Chem. 2007 Mar 16;282(11):8533-44. doi: 10.1074/jbc.M611107200. Epub 2007 Jan 19. J Biol Chem. 2007. PMID: 17237233 Free article.
The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate.
Kitagawa H, Shimakawa H, Sugahara K. Kitagawa H, et al. Among authors: sugahara k. J Biol Chem. 1999 May 14;274(20):13933-7. doi: 10.1074/jbc.274.20.13933. J Biol Chem. 1999. PMID: 10318803 Free article.
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.
Kitagawa H, Egusa N, Tamura JI, Kusche-Gullberg M, Lindahl U, Sugahara K. Kitagawa H, et al. Among authors: sugahara k. J Biol Chem. 2001 Feb 16;276(7):4834-8. doi: 10.1074/jbc.C000835200. Epub 2000 Dec 19. J Biol Chem. 2001. PMID: 11121397 Free article.
900 results