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Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis.
Kim BT, Kitagawa H, Tamura J, Saito T, Kusche-Gullberg M, Lindahl U, Sugahara K. Kim BT, et al. Among authors: tamura j. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7176-81. doi: 10.1073/pnas.131188498. Epub 2001 Jun 5. Proc Natl Acad Sci U S A. 2001. PMID: 11390981 Free PMC article.
Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.
Kitagawa H, Izumikawa T, Mizuguchi S, Dejima K, Nomura KH, Egusa N, Taniguchi F, Tamura J, Gengyo-Ando K, Mitani S, Nomura K, Sugahara K. Kitagawa H, et al. Among authors: tamura j. J Biol Chem. 2007 Mar 16;282(11):8533-44. doi: 10.1074/jbc.M611107200. Epub 2007 Jan 19. J Biol Chem. 2007. PMID: 17237233 Free article.
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.
Kitagawa H, Egusa N, Tamura JI, Kusche-Gullberg M, Lindahl U, Sugahara K. Kitagawa H, et al. Among authors: tamura ji. J Biol Chem. 2001 Feb 16;276(7):4834-8. doi: 10.1074/jbc.C000835200. Epub 2000 Dec 19. J Biol Chem. 2001. PMID: 11121397 Free article.
Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members.
Izumikawa T, Koike T, Shiozawa S, Sugahara K, Tamura J, Kitagawa H. Izumikawa T, et al. Among authors: tamura j. J Biol Chem. 2008 Apr 25;283(17):11396-406. doi: 10.1074/jbc.M707549200. Epub 2008 Mar 3. J Biol Chem. 2008. PMID: 18316376 Free article.
2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis.
Tone Y, Pedersen LC, Yamamoto T, Izumikawa T, Kitagawa H, Nishihara J, Tamura J, Negishi M, Sugahara K. Tone Y, et al. Among authors: tamura j. J Biol Chem. 2008 Jun 13;283(24):16801-7. doi: 10.1074/jbc.M709556200. Epub 2008 Apr 9. J Biol Chem. 2008. PMID: 18400750 Free PMC article.
525 results