Rose J - Search Results

1

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: design of potent and specific 3,9-diazaspiro[5.5]undecanes.

Smyth MS, Rose J, Mehrotra MM, Heath J, Ruhter G, Schotten T, Seroogy J, Volkots D, Pandey A, Scarborough RM. Smyth MS, et al. Among authors: rose j. Bioorg Med Chem Lett. 2001 May 21;11(10):1289-92. doi: 10.1016/s0960-894x(01)00215-3. Bioorg Med Chem Lett. 2001. PMID: 11392539

2

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes.

Mehrotra MM, Heath JA, Rose JW, Smyth MS, Seroogy J, Volkots DL, Ruhter G, Schotten T, Alaimo L, Park G, Pandey A, Scarborough RM. Mehrotra MM, et al. Among authors: rose jw. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1103-7. doi: 10.1016/s0960-894x(02)00095-1. Bioorg Med Chem Lett. 2002. PMID: 11909727

3

Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family.

Pandey A, Volkots DL, Seroogy JM, Rose JW, Yu JC, Lambing JL, Hutchaleelaha A, Hollenbach SJ, Abe K, Giese NA, Scarborough RM. Pandey A, et al. Among authors: rose jw. J Med Chem. 2002 Aug 15;45(17):3772-93. doi: 10.1021/jm020143r. J Med Chem. 2002. PMID: 12166950

4

Discovery of novel 2,8-diazaspiro[4.5]decanes as orally active glycoprotein IIb-IIIa antagonists.

Mehrotra MM, Heath JA, Smyth MS, Pandey A, Rose JW, Seroogy JM, Volkots DL, Nannizzi-Alaimo L, Park GL, Lambing JL, Hollenbach SJ, Scarborough RM. Mehrotra MM, et al. Among authors: rose jw. J Med Chem. 2004 Apr 8;47(8):2037-61. doi: 10.1021/jm030354b. J Med Chem. 2004. PMID: 15056002

5

Design of potent and specific integrin antagonists. Peptide antagonists with high specificity for glycoprotein IIb-IIIa.

Scarborough RM, Naughton MA, Teng W, Rose JW, Phillips DR, Nannizzi L, Arfsten A, Campbell AM, Charo IF. Scarborough RM, et al. Among authors: rose jw. J Biol Chem. 1993 Jan 15;268(2):1066-73. J Biol Chem. 1993. PMID: 8419315 Free article.

6

Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-alpha-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors.

Su T, Naughton MA, Smyth MS, Rose JW, Arfsten AE, McCowan JR, Jakubowski JA, Wyss VL, Ruterbories KJ, Sall DJ, Scarborough RM. Su T, et al. Among authors: rose jw. J Med Chem. 1997 Dec 19;40(26):4308-18. doi: 10.1021/jm9704863. J Med Chem. 1997. PMID: 9435900

7

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 2: design of potent antagonists containing the 3-azaspiro[5.5]undecanes.

Pandey A, Seroogy J, Volkots D, Smyth MS, Rose J, Mehrotra MM, Heath J, Ruhter G, Schotten T, Scarborough RM. Pandey A, et al. Among authors: rose j. Bioorg Med Chem Lett. 2001 May 21;11(10):1293-6. doi: 10.1016/s0960-894x(01)00216-5. Bioorg Med Chem Lett. 2001. PMID: 11392540

8

Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri.

Scarborough RM, Rose JW, Hsu MA, Phillips DR, Fried VA, Campbell AM, Nannizzi L, Charo IF. Scarborough RM, et al. Among authors: rose jw. J Biol Chem. 1991 May 25;266(15):9359-62. J Biol Chem. 1991. PMID: 2033037 Free article.

9

Characterization of the integrin specificities of disintegrins isolated from American pit viper venoms.

Scarborough RM, Rose JW, Naughton MA, Phillips DR, Nannizzi L, Arfsten A, Campbell AM, Charo IF. Scarborough RM, et al. Among authors: rose jw. J Biol Chem. 1993 Jan 15;268(2):1058-65. J Biol Chem. 1993. PMID: 8419314 Free article.

10

Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists.

Sall DJ, Arfsten AE, Bastian JA, Denney ML, Harms CS, McCowan JR, Morin JM Jr, Rose JW, Scarborough RM, Smyth MS, Um SL, Utterback BG, Vasileff RT, Wikel JH, Wyss VL, Jakubowski JA. Sall DJ, et al. Among authors: rose jw. J Med Chem. 1997 Aug 29;40(18):2843-57. doi: 10.1021/jm970020k. J Med Chem. 1997. PMID: 9288166

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