Karlsson A - Search Results

1

Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.

Manfredini S, Baraldi PG, Durini E, Porcu L, Angusti A, Vertuani S, Solaroli N, De Clercq E, Karlsson A, Balzarini J. Manfredini S, et al. Among authors: karlsson a. Bioorg Med Chem Lett. 2001 May 21;11(10):1329-32. doi: 10.1016/s0960-894x(01)00207-4. Bioorg Med Chem Lett. 2001. PMID: 11392548

2

Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity.

Ciliberti N, Manfredini S, Angusti A, Durini E, Solaroli N, Vertuani S, Buzzoni L, Bonache MC, Ben-Shalom E, Karlsson A, Saada A, Balzarini J. Ciliberti N, et al. Among authors: karlsson a. Bioorg Med Chem. 2007 Apr 15;15(8):3065-81. doi: 10.1016/j.bmc.2007.01.049. Epub 2007 Feb 2. Bioorg Med Chem. 2007. PMID: 17324575

3

3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase.

Van Poecke S, Negri A, Gago F, Van Daele I, Solaroli N, Karlsson A, Balzarini J, Van Calenbergh S. Van Poecke S, et al. Among authors: karlsson a. J Med Chem. 2010 Apr 8;53(7):2902-12. doi: 10.1021/jm901532h. J Med Chem. 2010. PMID: 20218622 Free article.

4

5'-Phosphoramidates and 5'-diphosphates of 2'-O-allyl-beta-D-arabinofuranosyluracil, -cytosine, and -adenine: inhibition of ribonucleotide reductase.

Manfredini S, Baraldi PG, Durini E, Vertuani S, Balzarini J, De Clercq E, Karlsson A, Buzzoni V, Thelander L. Manfredini S, et al. Among authors: karlsson a. J Med Chem. 1999 Aug 26;42(17):3243-50. doi: 10.1021/jm9807095. J Med Chem. 1999. PMID: 10464011

5

Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.

Hernández AI, Balzarini J, Karlsson A, Camarasa MJ, Pérez-Pérez MJ. Hernández AI, et al. Among authors: karlsson a. J Med Chem. 2002 Sep 12;45(19):4254-63. doi: 10.1021/jm011128+. J Med Chem. 2002. PMID: 12213066

6

Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase: replacement of a triphenylmethoxy moiety with substituted amines and carboxamides.

Hernández AI, Balzarini J, Rodríguez-Barrios F, San-Félix A, Karlsson A, Gago F, Camarasa MJ, Pérez-Pérez MJ. Hernández AI, et al. Among authors: karlsson a. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3027-30. doi: 10.1016/s0960-894x(03)00639-5. Bioorg Med Chem Lett. 2003. PMID: 12941326

7

Synthesis and evaluation of thymine-derived carboxamides against mitochondrial thymidine kinase (TK-2) and related enzymes.

Priego EM, Balzarini J, Karlsson A, Camarasa MJ, Pérez-Pérez MJ. Priego EM, et al. Among authors: karlsson a. Bioorg Med Chem. 2004 Oct 1;12(19):5079-90. doi: 10.1016/j.bmc.2004.07.036. Bioorg Med Chem. 2004. PMID: 15351391

8

N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.

Hernandez AI, Familiar O, Negri A, Rodríguez-Barrios F, Gago F, Karlsson A, Camarasa MJ, Balzarini J, Pérez-Pérez MJ. Hernandez AI, et al. Among authors: karlsson a. J Med Chem. 2006 Dec 28;49(26):7766-73. doi: 10.1021/jm0610550. J Med Chem. 2006. PMID: 17181158

9

Synthesis, modeling and evaluation of 3'-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3'-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors.

Van Poecke S, Negri A, Janssens J, Solaroli N, Karlsson A, Gago F, Balzarini J, Van Calenbergh S. Van Poecke S, et al. Among authors: karlsson a. Org Biomol Chem. 2011 Feb 7;9(3):892-901. doi: 10.1039/c0ob00591f. Epub 2010 Dec 2. Org Biomol Chem. 2011. PMID: 21127790

10

Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.

Quintiliani M, Persoons L, Solaroli N, Karlsson A, Andrei G, Snoeck R, Balzarini J, McGuigan C. Quintiliani M, et al. Among authors: karlsson a. Bioorg Med Chem. 2011 Jul 15;19(14):4338-45. doi: 10.1016/j.bmc.2011.05.037. Epub 2011 May 27. Bioorg Med Chem. 2011. PMID: 21696963 Free PMC article.

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