Solaroli N - Search Results

1

Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.

Manfredini S, Baraldi PG, Durini E, Porcu L, Angusti A, Vertuani S, Solaroli N, De Clercq E, Karlsson A, Balzarini J. Manfredini S, et al. Among authors: solaroli n. Bioorg Med Chem Lett. 2001 May 21;11(10):1329-32. doi: 10.1016/s0960-894x(01)00207-4. Bioorg Med Chem Lett. 2001. PMID: 11392548

2

Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity.

Ciliberti N, Manfredini S, Angusti A, Durini E, Solaroli N, Vertuani S, Buzzoni L, Bonache MC, Ben-Shalom E, Karlsson A, Saada A, Balzarini J. Ciliberti N, et al. Among authors: solaroli n. Bioorg Med Chem. 2007 Apr 15;15(8):3065-81. doi: 10.1016/j.bmc.2007.01.049. Epub 2007 Feb 2. Bioorg Med Chem. 2007. PMID: 17324575

3

3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase.

Van Poecke S, Negri A, Gago F, Van Daele I, Solaroli N, Karlsson A, Balzarini J, Van Calenbergh S. Van Poecke S, et al. Among authors: solaroli n. J Med Chem. 2010 Apr 8;53(7):2902-12. doi: 10.1021/jm901532h. J Med Chem. 2010. PMID: 20218622 Free article.

4

Design, synthesis and binding at cloned muscarinic receptors of N-[5-(1'-substituted-acetoxymethyl)-3-oxadiazolyl] and N-[4-(1'-substituted-acetoxymethyl)-2-dioxolanyl] dialkyl amines.

Manfredini S, Lampronti I, Vertuani S, Solaroli N, Recanatini M, Bryan D, McKinney M. Manfredini S, et al. Among authors: solaroli n. Bioorg Med Chem. 2000 Jul;8(7):1559-66. doi: 10.1016/s0968-0896(00)00092-4. Bioorg Med Chem. 2000. PMID: 10976504

5

Design, synthesis and anti flaviviridae activity of N(6)-, 5',3'-O- and 5',2'-O-substituted adenine nucleoside analogs.

Angusti A, Manfredini S, Durini E, Ciliberti N, Vertuani S, Solaroli N, Pricl S, Ferrone M, Fermeglia M, Loddo R, Secci B, Visioli A, Sanna T, Collu G, Pezzullo M, La Colla P. Angusti A, et al. Among authors: solaroli n. Chem Pharm Bull (Tokyo). 2008 Apr;56(4):423-32. doi: 10.1248/cpb.56.423. Chem Pharm Bull (Tokyo). 2008. PMID: 18379085 Free article.

6

Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.

Quintiliani M, Persoons L, Solaroli N, Karlsson A, Andrei G, Snoeck R, Balzarini J, McGuigan C. Quintiliani M, et al. Among authors: solaroli n. Bioorg Med Chem. 2011 Jul 15;19(14):4338-45. doi: 10.1016/j.bmc.2011.05.037. Epub 2011 May 27. Bioorg Med Chem. 2011. PMID: 21696963 Free PMC article.

7

Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity.

Manfredini S, Solaroli N, Angusti A, Nalin F, Durini E, Vertuani S, Pricl S, Ferrone M, Spadari S, Focher F, Verri A, De Clercq E, Balzarini J. Manfredini S, et al. Among authors: solaroli n. Antivir Chem Chemother. 2003 Jul;14(4):183-94. doi: 10.1177/095632020301400403. Antivir Chem Chemother. 2003. PMID: 14582847 Free article.

8

Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design.

El Omari K, Solaroli N, Karlsson A, Balzarini J, Stammers DK. El Omari K, et al. Among authors: solaroli n. BMC Struct Biol. 2006 Oct 24;6:22. doi: 10.1186/1472-6807-6-22. BMC Struct Biol. 2006. PMID: 17062140 Free PMC article.

9

Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity.

Balzarini J, Van Daele I, Negri A, Solaroli N, Karlsson A, Liekens S, Gago F, Van Calenbergh S. Balzarini J, et al. Among authors: solaroli n. Mol Pharmacol. 2009 May;75(5):1127-36. doi: 10.1124/mol.108.053785. Epub 2009 Feb 20. Mol Pharmacol. 2009. PMID: 19233899

10

Synthesis, modeling and evaluation of 3'-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3'-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors.

Van Poecke S, Negri A, Janssens J, Solaroli N, Karlsson A, Gago F, Balzarini J, Van Calenbergh S. Van Poecke S, et al. Among authors: solaroli n. Org Biomol Chem. 2011 Feb 7;9(3):892-901. doi: 10.1039/c0ob00591f. Epub 2010 Dec 2. Org Biomol Chem. 2011. PMID: 21127790

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