Yu QS - Search Results

1

Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development.

Shaw KT, Utsuki T, Rogers J, Yu QS, Sambamurti K, Brossi A, Ge YW, Lahiri DK, Greig NH. Shaw KT, et al. Among authors: yu qs. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7605-10. doi: 10.1073/pnas.131152998. Epub 2001 Jun 12. Proc Natl Acad Sci U S A. 2001. PMID: 11404470 Free PMC article.

2

Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action.

Yu Q, Holloway HW, Flippen-Anderson JL, Hoffman B, Brossi A, Greig NH. Yu Q, et al. J Med Chem. 2001 Nov 22;44(24):4062-71. doi: 10.1021/jm010080x. J Med Chem. 2001. PMID: 11708910

3

The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics.

Greig NH, De Micheli E, Holloway HW, Yu QS, Utsuki T, Perry TA, Brossi A, Ingram DK, Deutsch J, Lahiri DK, Soncrant TT. Greig NH, et al. Among authors: yu qs. Acta Neurol Scand Suppl. 2000;176:74-84. doi: 10.1034/j.1600-0404.2000.00311.x. Acta Neurol Scand Suppl. 2000. PMID: 11261809

4

Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease.

Yu Q, Holloway HW, Utsuki T, Brossi A, Greig NH. Yu Q, et al. J Med Chem. 1999 May 20;42(10):1855-61. doi: 10.1021/jm980459s. J Med Chem. 1999. PMID: 10346939

5

A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase.

Greig NH, Utsuki T, Yu Q, Zhu X, Holloway HW, Perry T, Lee B, Ingram DK, Lahiri DK. Greig NH, et al. Curr Med Res Opin. 2001;17(3):159-65. doi: 10.1185/0300799039117057. Curr Med Res Opin. 2001. PMID: 11900310 Review.

6

Phenserine, a novel acetylcholinesterase inhibitor, attenuates impaired learning of rats in a 14-unit T-maze induced by blockade of the N-methyl-D-aspartate receptor.

Patel N, Spangler EL, Greig NH, Yu QS, Ingram DK, Meyer RC. Patel N, et al. Among authors: yu qs. Neuroreport. 1998 Jan 5;9(1):171-6. doi: 10.1097/00001756-199801050-00035. Neuroreport. 1998. PMID: 9592071

7

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

Culmsee C, Zhu X, Yu QS, Chan SL, Camandola S, Guo Z, Greig NH, Mattson MP. Culmsee C, et al. Among authors: yu qs. J Neurochem. 2001 Apr;77(1):220-8. doi: 10.1046/j.1471-4159.2001.t01-1-00220.x. J Neurochem. 2001. PMID: 11279278 Free article.

8

Total syntheses and anticholinesterase activities of (3aS)-N(8)-norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues.

Yu QS, Pei XF, Holloway HW, Greig NH, Brossi A. Yu QS, et al. J Med Chem. 1997 Aug 29;40(18):2895-901. doi: 10.1021/jm970210v. J Med Chem. 1997. PMID: 9288171

9

Post-trauma administration of the pifithrin-α oxygen analog improves histological and functional outcomes after experimental traumatic brain injury.

Yang LY, Chu YH, Tweedie D, Yu QS, Pick CG, Hoffer BJ, Greig NH, Wang JY. Yang LY, et al. Among authors: yu qs. Exp Neurol. 2015 Jul;269:56-66. doi: 10.1016/j.expneurol.2015.03.015. Epub 2015 Mar 24. Exp Neurol. 2015. PMID: 25819102 Free PMC article.

10

Comparative inhibitory effects of various physostigmine analogs against acetyl- and butyrylcholinesterases.

Atack JR, Yu QS, Soncrant TT, Brossi A, Rapoport SI. Atack JR, et al. Among authors: yu qs. J Pharmacol Exp Ther. 1989 Apr;249(1):194-202. J Pharmacol Exp Ther. 1989. PMID: 2709330

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