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Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: structure-activity relationships of the 4-anilino group.
Sirisoma N, Kasibhatla S, Nguyen B, Pervin A, Wang Y, Claassen G, Tseng B, Drewe J, Cai SX. Sirisoma N, et al. Bioorg Med Chem. 2006 Dec 1;14(23):7761-73. doi: 10.1016/j.bmc.2006.08.002. Epub 2006 Aug 21. Bioorg Med Chem. 2006. PMID: 16919962
Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure-activity relationships of the 1- and 3-positions.
Kemnitzer W, Kuemmerle J, Jiang S, Zhang HZ, Sirisoma N, Kasibhatla S, Crogan-Grundy C, Tseng B, Drewe J, Cai SX. Kemnitzer W, et al. Among authors: sirisoma n. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6259-64. doi: 10.1016/j.bmcl.2008.09.110. Epub 2008 Oct 17. Bioorg Med Chem Lett. 2008. PMID: 18952423
Discovery of substituted 4-anilino-2-arylpyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 2. Structure-activity relationships of the 2-aryl group.
Sirisoma N, Pervin A, Nguyen B, Crogan-Grundy C, Kasibhatla S, Tseng B, Drewe J, Cai SX. Sirisoma N, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2305-9. doi: 10.1016/j.bmcl.2009.02.074. Epub 2009 Feb 23. Bioorg Med Chem Lett. 2009. PMID: 19285392
Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the carboxamide group.
Kemnitzer W, Sirisoma N, Nguyen B, Jiang S, Kasibhatla S, Crogan-Grundy C, Tseng B, Drewe J, Cai SX. Kemnitzer W, et al. Among authors: sirisoma n. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3045-9. doi: 10.1016/j.bmcl.2009.04.009. Epub 2009 Apr 8. Bioorg Med Chem Lett. 2009. PMID: 19394823
Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2: Structure-activity relationships of the 4-, 5-, 6-, 7- and 8-positions.
Kemnitzer W, Kuemmerle J, Jiang S, Sirisoma N, Kasibhatla S, Crogan-Grundy C, Tseng B, Drewe J, Cai SX. Kemnitzer W, et al. Among authors: sirisoma n. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3481-4. doi: 10.1016/j.bmcl.2009.05.012. Epub 2009 May 8. Bioorg Med Chem Lett. 2009. PMID: 19467598
Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity.
Sirisoma N, Kasibhatla S, Pervin A, Zhang H, Jiang S, Willardsen JA, Anderson MB, Baichwal V, Mather GG, Jessing K, Hussain R, Hoang K, Pleiman CM, Tseng B, Drewe J, Cai SX. Sirisoma N, et al. J Med Chem. 2008 Aug 14;51(15):4771-9. doi: 10.1021/jm8003653. Epub 2008 Jul 24. J Med Chem. 2008. PMID: 18651728
21 results