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Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein.
Fitzjohn SM, Morton RA, Kuenzi F, Rosahl TW, Shearman M, Lewis H, Smith D, Reynolds DS, Davies CH, Collingridge GL, Seabrook GR. Fitzjohn SM, et al. Among authors: shearman m. J Neurosci. 2001 Jul 1;21(13):4691-8. doi: 10.1523/JNEUROSCI.21-13-04691.2001. J Neurosci. 2001. PMID: 11425896 Free PMC article.
The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse.
Best JD, Smith DW, Reilly MA, O'Donnell R, Lewis HD, Ellis S, Wilkie N, Rosahl TW, Laroque PA, Boussiquet-Leroux C, Churcher I, Atack JR, Harrison T, Shearman MS. Best JD, et al. J Pharmacol Exp Ther. 2007 Feb;320(2):552-8. doi: 10.1124/jpet.106.114330. Epub 2006 Nov 10. J Pharmacol Exp Ther. 2007. PMID: 17099072
Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease.
Rival T, Page RM, Chandraratna DS, Sendall TJ, Ryder E, Liu B, Lewis H, Rosahl T, Hider R, Camargo LM, Shearman MS, Crowther DC, Lomas DA. Rival T, et al. Among authors: shearman ms. Eur J Neurosci. 2009 Apr;29(7):1335-47. doi: 10.1111/j.1460-9568.2009.06701.x. Epub 2009 Mar 23. Eur J Neurosci. 2009. PMID: 19519625 Free PMC article.
LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.
Majercak J, Ray WJ, Espeseth A, Simon A, Shi XP, Wolffe C, Getty K, Marine S, Stec E, Ferrer M, Strulovici B, Bartz S, Gates A, Xu M, Huang Q, Ma L, Shughrue P, Burchard J, Colussi D, Pietrak B, Kahana J, Beher D, Rosahl T, Shearman M, Hazuda D, Sachs AB, Koblan KS, Seabrook GR, Stone DJ. Majercak J, et al. Among authors: shearman m. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17967-72. doi: 10.1073/pnas.0605461103. Epub 2006 Nov 10. Proc Natl Acad Sci U S A. 2006. PMID: 17098871 Free PMC article.
126 results