Horwell DC - Search Results

1

Utilization of an intramolecular hydrogen bond to increase the CNS penetration of an NK(1) receptor antagonist.

Ashwood VA, Field MJ, Horwell DC, Julien-Larose C, Lewthwaite RA, McCleary S, Pritchard MC, Raphy J, Singh L. Ashwood VA, et al. Among authors: horwell dc. J Med Chem. 2001 Jul 5;44(14):2276-85. doi: 10.1021/jm010825z. J Med Chem. 2001. PMID: 11428921

2

Rationally designed "dipeptoid" analogues of CCK. Acid mimics of the potent and selective non-peptide CCK-B receptor antagonist CI-988.

Drysdale MJ, Pritchard MC, Horwell DC. Drysdale MJ, et al. Among authors: horwell dc. J Med Chem. 1992 Jul 10;35(14):2573-81. doi: 10.1021/jm00092a007. J Med Chem. 1992. PMID: 1635058

3

Rationally designed "dipeptoid" analogues of CCK. alpha-Methyltryptophan derivatives as highly selective and orally active gastrin and CCK-B antagonists with potent anxiolytic properties.

Horwell DC, Hughes J, Hunter JC, Pritchard MC, Richardson RS, Roberts E, Woodruff GN. Horwell DC, et al. J Med Chem. 1991 Jan;34(1):404-14. doi: 10.1021/jm00105a062. J Med Chem. 1991. PMID: 1671419

4

Rational design of high affinity tachykinin NK1 receptor antagonists.

Boyle S, Guard S, Higginbottom M, Horwell DC, Howson W, McKnight AT, Martin K, Pritchard MC, O'Toole J, Raphy J, et al. Boyle S, et al. Among authors: horwell dc. Bioorg Med Chem. 1994 May;2(5):357-70. doi: 10.1016/s0968-0896(00)82192-6. Bioorg Med Chem. 1994. PMID: 7922147

5

Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.

Boden P, Eden JM, Hodgson J, Horwell DC, Hughes J, McKnight AT, Lewthwaite RA, Pritchard MC, Raphy J, Meecham K, Ratcliffe GS, Suman-Chauhan N, Woodruff GN. Boden P, et al. Among authors: horwell dc. J Med Chem. 1996 Apr 12;39(8):1664-75. doi: 10.1021/jm950892r. J Med Chem. 1996. PMID: 8648606

6

PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist.

Ashwood V, Brownhill V, Higginbottom M, Horwell DC, Hughes J, Lewthwaite RA, McKnight AT, Pinnock RD, Pritchard MC, Suman-Chauhan N, Webb C, Williams SC. Ashwood V, et al. Among authors: horwell dc. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2589-94. doi: 10.1016/s0960-894x(98)00462-4. Bioorg Med Chem Lett. 1998. PMID: 9873586

7

Synthesis and biological evaluation of conformationally restricted Gabapentin analogues.

Receveur JM, Bryans JS, Field MJ, Singh L, Horwell DC. Receveur JM, et al. Among authors: horwell dc. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2329-34. doi: 10.1016/s0960-894x(99)00383-2. Bioorg Med Chem Lett. 1999. PMID: 10476863

8

'Targeted' molecular diversity: design and development of non-peptide antagonists for cholecystokinin and tachykinin receptors.

Horwell D, Pritchard M, Raphy J, Ratcliffe G. Horwell D, et al. Immunopharmacology. 1996 Jun;33(1-3):68-72. doi: 10.1016/0162-3109(96)00058-6. Immunopharmacology. 1996. PMID: 8856117 Review.

9

Cholecystokinin dipeptoid antagonists: design, synthesis, and anxiolytic profile of some novel CCK-A and CCK-B selective and "mixed" CCK-A/CCK-B antagonists.

Boden PR, Higginbottom M, Hill DR, Horwell DC, Hughes J, Rees DC, Roberts E, Singh L, Suman-Chauhan N, Woodruff GN. Boden PR, et al. Among authors: horwell dc. J Med Chem. 1993 Mar 5;36(5):552-65. doi: 10.1021/jm00057a005. J Med Chem. 1993. PMID: 7684452

10

Rational design of high affinity tachykinin NK2 receptor antagonists.

Boyle S, Guard S, Hodgson J, Horwell DC, Howson W, Hughes J, McKnight A, Martin K, Pritchard MC, Watling KJ, et al. Boyle S, et al. Among authors: horwell dc. Bioorg Med Chem. 1994 Feb;2(2):101-13. doi: 10.1016/s0968-0896(00)82006-4. Bioorg Med Chem. 1994. PMID: 7922121

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