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A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging We gratefully acknowledge financial support from Pfizer Global Research and Development, the University of Ferrara (Italy, Postdoctoral Fellowship to A.M.), the EU (Marie Curie Fellowship to F.R.), and a Novartis Research Fellowship (to S.V.L.).
Ley SV, Massi A, Rodríguez F, Horwell DC, Lewthwaite RA, Pritchard MC, Reid AM. Ley SV, et al. Among authors: lewthwaite ra. Angew Chem Int Ed Engl. 2001 Mar 16;40(6):1053-1055. doi: 10.1002/1521-3773(20010316)40:6<1053::aid-anie10530>3.0.co;2-d. Angew Chem Int Ed Engl. 2001. PMID: 11268070 No abstract available.
Inhalation by design: novel ultra-long-acting β(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup.
Glossop PA, Lane CA, Price DA, Bunnage ME, Lewthwaite RA, James K, Brown AD, Yeadon M, Perros-Huguet C, Trevethick MA, Clarke NP, Webster R, Jones RM, Burrows JL, Feeder N, Taylor SC, Spence FJ. Glossop PA, et al. Among authors: lewthwaite ra. J Med Chem. 2010 Sep 23;53(18):6640-52. doi: 10.1021/jm1005989. J Med Chem. 2010. PMID: 20804199
Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.
Millan DS, Bunnage ME, Burrows JL, Butcher KJ, Dodd PG, Evans TJ, Fairman DA, Hughes SJ, Kilty IC, Lemaitre A, Lewthwaite RA, Mahnke A, Mathias JP, Philip J, Smith RT, Stefaniak MH, Yeadon M, Phillips C. Millan DS, et al. Among authors: lewthwaite ra. J Med Chem. 2011 Nov 24;54(22):7797-814. doi: 10.1021/jm200677b. Epub 2011 Oct 28. J Med Chem. 2011. PMID: 21888439
The discovery of long acting beta2-adrenoreceptor agonists.
Brown AD, Bunnage ME, Glossop PA, James K, Jones R, Lane CA, Lewthwaite RA, Mantell S, Perros-Huguet C, Price DA, Trevethick M, Webster R. Brown AD, et al. Among authors: lewthwaite ra. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4012-5. doi: 10.1016/j.bmcl.2007.04.081. Epub 2007 Apr 29. Bioorg Med Chem Lett. 2007. PMID: 17498952
Fragment based discovery of a novel and selective PI3 kinase inhibitor.
Hughes SJ, Millan DS, Kilty IC, Lewthwaite RA, Mathias JP, O'Reilly MA, Pannifer A, Phelan A, Stühmeier F, Baldock DA, Brown DG. Hughes SJ, et al. Among authors: lewthwaite ra. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6586-90. doi: 10.1016/j.bmcl.2011.07.117. Epub 2011 Aug 6. Bioorg Med Chem Lett. 2011. PMID: 21925880
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