Gray A - Search Results

1

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.

Leslie NR, Bennett D, Gray A, Pass I, Hoang-Xuan K, Downes CP. Leslie NR, et al. Among authors: gray a. Biochem J. 2001 Jul 15;357(Pt 2):427-35. doi: 10.1042/0264-6021:3570427. Biochem J. 2001. PMID: 11439092 Free PMC article.

2

Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.

Maccario H, Perera NM, Gray A, Downes CP, Leslie NR. Maccario H, et al. Among authors: gray a. J Biol Chem. 2010 Apr 23;285(17):12620-8. doi: 10.1074/jbc.M109.072280. Epub 2010 Feb 22. J Biol Chem. 2010. PMID: 20177066 Free PMC article.

3

Redox regulation of PI 3-kinase signalling via inactivation of PTEN.

Leslie NR, Bennett D, Lindsay YE, Stewart H, Gray A, Downes CP. Leslie NR, et al. Among authors: gray a. EMBO J. 2003 Oct 15;22(20):5501-10. doi: 10.1093/emboj/cdg513. EMBO J. 2003. PMID: 14532122 Free PMC article.

4

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1.

Fleming IN, Batty IH, Prescott AR, Gray A, Kular GS, Stewart H, Downes CP. Fleming IN, et al. Among authors: gray a. Biochem J. 2004 Sep 15;382(Pt 3):857-65. doi: 10.1042/BJ20040916. Biochem J. 2004. PMID: 15242348 Free PMC article.

5

The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2.

Batty IH, van der Kaay J, Gray A, Telfer JF, Dixon MJ, Downes CP. Batty IH, et al. Among authors: gray a. Biochem J. 2007 Oct 15;407(2):255-66. doi: 10.1042/BJ20070558. Biochem J. 2007. PMID: 17672824 Free PMC article.

6

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.

Currie RA, Walker KS, Gray A, Deak M, Casamayor A, Downes CP, Cohen P, Alessi DR, Lucocq J. Currie RA, et al. Among authors: gray a. Biochem J. 1999 Feb 1;337 ( Pt 3)(Pt 3):575-83. Biochem J. 1999. PMID: 9895304 Free PMC article.

7

The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo.

Gray A, Van Der Kaay J, Downes CP. Gray A, et al. Biochem J. 1999 Dec 15;344 Pt 3(Pt 3):929-36. Biochem J. 1999. PMID: 10585883 Free PMC article.

8

Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase.

Leslie NR, Gray A, Pass I, Orchiston EA, Downes CP. Leslie NR, et al. Among authors: gray a. Biochem J. 2000 Mar 15;346 Pt 3(Pt 3):827-33. Biochem J. 2000. PMID: 10698713 Free PMC article.

9

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components.

Fleming IN, Gray A, Downes CP. Fleming IN, et al. Among authors: gray a. Biochem J. 2000 Oct 1;351(Pt 1):173-82. doi: 10.1042/0264-6021:3510173. Biochem J. 2000. PMID: 10998360 Free PMC article.

10

A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B.

Peyrollier K, Hajduch E, Gray A, Litherland GJ, Prescott AR, Leslie NR, Hundal HS. Peyrollier K, et al. Among authors: gray a. Biochem J. 2000 Dec 15;352 Pt 3(Pt 3):617-22. Biochem J. 2000. PMID: 11104665 Free PMC article.

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