Largis E - Search Results

1

Novel (4-piperidin-1-yl)-phenyl sulfonamides as potent and selective human beta(3) agonists.

Hu B, Ellingboe J, Han S, Largis E, Lim K, Malamas M, Mulvey R, Niu C, Oliphant A, Pelletier J, Singanallore T, Sum FW, Tillett J, Wong V. Hu B, et al. Among authors: largis e. Bioorg Med Chem. 2001 Aug;9(8):2045-59. doi: 10.1016/s0968-0896(01)00114-6. Bioorg Med Chem. 2001. PMID: 11504641

2

Novel substituted 4-aminomethylpiperidines as potent and selective human beta3-agonists. Part 1: aryloxypropanolaminomethylpiperidines.

Steffan RJ, Ashwell MA, Solvibile WR, Matelan E, Largis E, Han S, Tillet J, Mulvey R. Steffan RJ, et al. Among authors: largis e. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2957-61. doi: 10.1016/s0960-894x(02)00607-8. Bioorg Med Chem Lett. 2002. PMID: 12270183

3

Novel substituted 4-aminomethylpiperidines as potent and selective human beta3-agonists. Part 2: arylethanolaminomethylpiperidines.

Steffan RJ, Ashwell MA, Solvibile WR, Matelan E, Largis E, Han S, Tillet J, Mulvey R. Steffan RJ, et al. Among authors: largis e. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2963-7. doi: 10.1016/s0960-894x(02)00608-x. Bioorg Med Chem Lett. 2002. PMID: 12270184

4

Cyclic amine sulfonamides as linkers in the design and synthesis of novel human beta(3) adrenergic receptor agonists.

Sum FW, Wong V, Han S, Largis E, Mulvey R, Tillett J. Sum FW, et al. Among authors: largis e. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2191-4. doi: 10.1016/s0960-894x(03)00387-1. Bioorg Med Chem Lett. 2003. PMID: 12798332

5

Prodrugs of CL316243: a selective beta3-adrenergic receptor agonist for treating obesity and diabetes.

Sum FW, Gilbert A, Venkatesan AM, Lim K, Wong V, O'Dell M, Francisco G, Chen Z, Grosu G, Baker J, Ellingboe J, Malamas M, Gunawan I, Primeau J, Largis E, Steiner K. Sum FW, et al. Among authors: largis e. Bioorg Med Chem Lett. 1999 Jul 19;9(14):1921-6. doi: 10.1016/s0960-894x(99)00316-9. Bioorg Med Chem Lett. 1999. PMID: 10450954

6

2,4-Thiazolidinediones as potent and selective human beta3 agonists.

Hu B, Ellingboe J, Gunawan I, Han S, Largis E, Li Z, Malamas M, Mulvey R, Oliphant A, Sum FW, Tillett J, Wong V. Hu B, et al. Among authors: largis e. Bioorg Med Chem Lett. 2001 Mar 26;11(6):757-60. doi: 10.1016/s0960-894x(01)00063-4. Bioorg Med Chem Lett. 2001. PMID: 11277513

7

(4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists.

Hu B, Ellingboe J, Han S, Largis E, Mulvey R, Oliphant A, Sum FW, Tillett J. Hu B, et al. Among authors: largis e. J Med Chem. 2001 Apr 26;44(9):1456-66. doi: 10.1021/jm000544b. J Med Chem. 2001. PMID: 11311069

8

New oxadiazolidinedione derivatives as potent and selective human beta3 agonists.

Hu B, Malamas M, Ellingboe J, Largis E, Han S, Mulvey R, Tillett J. Hu B, et al. Among authors: largis e. Bioorg Med Chem Lett. 2001 Apr 23;11(8):981-4. doi: 10.1016/s0960-894x(01)00147-0. Bioorg Med Chem Lett. 2001. PMID: 11327605

9

4-Aminopiperidine ureas as potent selective agonists of the human beta(3)-adrenergic receptor.

Ashwell MA, Solvibile WR Jr, Han S, Largis E, Mulvey R, Tillet J. Ashwell MA, et al. Among authors: largis e. Bioorg Med Chem Lett. 2001 Dec 17;11(24):3123-7. doi: 10.1016/s0960-894x(01)00645-x. Bioorg Med Chem Lett. 2001. PMID: 11720857

10

Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.

Bloom JD, Dutia MD, Johnson BD, Wissner A, Burns MG, Largis EE, Dolan JA, Claus TH. Bloom JD, et al. Among authors: largis ee. J Med Chem. 1992 Aug 7;35(16):3081-4. doi: 10.1021/jm00094a025. J Med Chem. 1992. PMID: 1354264 No abstract available.

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