Griffiths RJ - Search Results

1

Induction of hepatic microsomal drug-metabolizing enzymes by inhibitors of 5-lipoxygenase (5-LO): studies in rats and 5-LO knockout mice.

Beierschmitt WP, McNeish JD, Griffiths RJ, Nagahisa A, Nakane M, Amacher DE. Beierschmitt WP, et al. Among authors: griffiths rj. Toxicol Sci. 2001 Sep;63(1):15-21. doi: 10.1093/toxsci/63.1.15. Toxicol Sci. 2001. PMID: 11509739

2

Collagen-induced arthritis is reduced in 5-lipoxygenase-activating protein-deficient mice.

Griffiths RJ, Smith MA, Roach ML, Stock JL, Stam EJ, Milici AJ, Scampoli DN, Eskra JD, Byrum RS, Koller BH, McNeish JD. Griffiths RJ, et al. J Exp Med. 1997 Mar 17;185(6):1123-9. doi: 10.1084/jem.185.6.1123. J Exp Med. 1997. PMID: 9091585 Free PMC article.

3

Tenidap inhibits 5-lipoxygenase product formation in vitro, but this activity is not observed in three animal models.

Carty TJ, Sweeney FJ, Griffiths RJ, Eskra JD, Ernest MJ, Pillar JS, Cheng JD, Loose LD, Joseph PA, Pazoles PP, Moore PF, Nagahisa A, Murase S, Kadin SB. Carty TJ, et al. Among authors: griffiths rj. Inflamm Res. 1997 May;46(5):168-79. doi: 10.1007/s000110050163. Inflamm Res. 1997. PMID: 9197987

4

Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice.

Nakagawa TY, Brissette WH, Lira PD, Griffiths RJ, Petrushova N, Stock J, McNeish JD, Eastman SE, Howard ED, Clarke SR, Rosloniec EF, Elliott EA, Rudensky AY. Nakagawa TY, et al. Among authors: griffiths rj. Immunity. 1999 Feb;10(2):207-17. doi: 10.1016/s1074-7613(00)80021-7. Immunity. 1999. PMID: 10072073 Free article.

5

Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis.

Griffiths RJ, Pettipher ER, Koch K, Farrell CA, Breslow R, Conklyn MJ, Smith MA, Hackman BC, Wimberly DJ, Milici AJ, et al. Griffiths RJ, et al. Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):517-21. doi: 10.1073/pnas.92.2.517. Proc Natl Acad Sci U S A. 1995. PMID: 7831322 Free PMC article.

6

Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.

Reiter LA, Robinson RP, McClure KF, Jones CS, Reese MR, Mitchell PG, Otterness IG, Bliven ML, Liras J, Cortina SR, Donahue KM, Eskra JD, Griffiths RJ, Lame ME, Lopez-Anaya A, Martinelli GJ, McGahee SM, Yocum SA, Lopresti-Morrow LL, Tobiassen LM, Vaughn-Bowser ML. Reiter LA, et al. Among authors: griffiths rj. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3389-95. doi: 10.1016/j.bmcl.2004.04.083. Bioorg Med Chem Lett. 2004. PMID: 15177439

7

Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors.

Perregaux DG, McNiff P, Laliberte R, Hawryluk N, Peurano H, Stam E, Eggler J, Griffiths R, Dombroski MA, Gabel CA. Perregaux DG, et al. J Pharmacol Exp Ther. 2001 Oct;299(1):187-97. J Pharmacol Exp Ther. 2001. PMID: 11561079

8

The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy.

Cheng JB, Watson JW, Pazoles CJ, Eskra JD, Griffiths RJ, Cohan VL, Turner CR, Showell HJ, Pettipher ER. Cheng JB, et al. Among authors: griffiths rj. J Pharmacol Exp Ther. 1997 Feb;280(2):621-6. J Pharmacol Exp Ther. 1997. PMID: 9023272

9

Altered cytokine production in mice lacking P2X(7) receptors.

Solle M, Labasi J, Perregaux DG, Stam E, Petrushova N, Koller BH, Griffiths RJ, Gabel CA. Solle M, et al. Among authors: griffiths rj. J Biol Chem. 2001 Jan 5;276(1):125-32. doi: 10.1074/jbc.M006781200. J Biol Chem. 2001. PMID: 11016935 Free article.

10

Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.

Freeman-Cook KD, Reiter LA, Noe MC, Antipas AS, Danley DE, Datta K, Downs JT, Eisenbeis S, Eskra JD, Garmene DJ, Greer EM, Griffiths RJ, Guzman R, Hardink JR, Janat F, Jones CS, Martinelli GJ, Mitchell PG, Laird ER, Liras JL, Lopresti-Morrow LL, Pandit J, Reilly UD, Robertson D, Vaughn-Bowser ML, Wolf-Gouviea LA, Yocum SA. Freeman-Cook KD, et al. Among authors: griffiths rj. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6529-34. doi: 10.1016/j.bmcl.2007.09.085. Epub 2007 Sep 29. Bioorg Med Chem Lett. 2007. PMID: 17935984

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