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A naturally occurring mutation K220T in the pleiotropic activator PrfA of Listeria monocytogenes results in a loss of virulence due to decreasing DNA-binding affinity.
Velge P, Herler M, Johansson J, Roche SM, Témoin S, Fedorov AA, Gracieux P, Almo SC, Goebel W, Cossart P. Velge P, et al. Among authors: herler m. Microbiology (Reading). 2007 Apr;153(Pt 4):995-1005. doi: 10.1099/mic.0.2006/002238-0. Microbiology (Reading). 2007. PMID: 17379709 Free article.