Gougoutas JZ - Search Results

1

Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1.

Ahmad S, Doweyko LM, Dugar S, Grazier N, Ngu K, Wu SC, Yost KJ, Chen BC, Gougoutas JZ, DiMarco JD, Lan SJ, Gavin BJ, Chen AY, Dorso CR, Serafino R, Kirby M, Atwal KS. Ahmad S, et al. Among authors: gougoutas jz. J Med Chem. 2001 Sep 27;44(20):3302-10. doi: 10.1021/jm010100v. J Med Chem. 2001. PMID: 11563929

2

Calcium entry blockers and activators: conformational and structural determinants of dihydropyrimidine calcium channel modulators.

Rovnyak GC, Kimball SD, Beyer B, Cucinotta G, DiMarco JD, Gougoutas J, Hedberg A, Malley M, McCarthy JP, Zhang R, et al. Rovnyak GC, et al. J Med Chem. 1995 Jan 6;38(1):119-29. doi: 10.1021/jm00001a017. J Med Chem. 1995. PMID: 7837222

3

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents.

Rovnyak GC, Atwal KS, Hedberg A, Kimball SD, Moreland S, Gougoutas JZ, O'Reilly BC, Schwartz J, Malley MF. Rovnyak GC, et al. Among authors: gougoutas jz. J Med Chem. 1992 Aug 21;35(17):3254-63. doi: 10.1021/jm00095a023. J Med Chem. 1992. PMID: 1387168

4

Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

Atwal KS, Rovnyak GC, Schwartz J, Moreland S, Hedberg A, Gougoutas JZ, Malley MF, Floyd DM. Atwal KS, et al. Among authors: gougoutas jz. J Med Chem. 1990 May;33(5):1510-5. doi: 10.1021/jm00167a035. J Med Chem. 1990. PMID: 2329573

5

Dihydropyrimidine calcium channel blockers. 2. 3-substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

Atwal KS, Rovnyak GC, Kimball SD, Floyd DM, Moreland S, Swanson BN, Gougoutas JZ, Schwartz J, Smillie KM, Malley MF. Atwal KS, et al. Among authors: gougoutas jz. J Med Chem. 1990 Sep;33(9):2629-35. doi: 10.1021/jm00171a044. J Med Chem. 1990. PMID: 2391701

6

Discovery of potent and muscle selective androgen receptor modulators through scaffold modifications.

Li JJ, Sutton JC, Nirschl A, Zou Y, Wang H, Sun C, Pi Z, Johnson R, Krystek SR Jr, Seethala R, Golla R, Sleph PG, Beehler BC, Grover GJ, Fura A, Vyas VP, Li CY, Gougoutas JZ, Galella MA, Zahler R, Ostrowski J, Hamann LG. Li JJ, et al. Among authors: gougoutas jz. J Med Chem. 2007 Jun 28;50(13):3015-25. doi: 10.1021/jm070312d. Epub 2007 Jun 7. J Med Chem. 2007. PMID: 17552509

7

One-pot synthesis and conformational features of n,n'-disubstituted ketene aminals.

Shi Y, Zhang J, Grazier N, Stein PD, Atwal KS, Traeger SC, Callahan SP, Malley MF, Galella MA, Gougoutas JZ. Shi Y, et al. Among authors: gougoutas jz. J Org Chem. 2004 Jan 9;69(1):188-91. doi: 10.1021/jo0352528. J Org Chem. 2004. PMID: 14703396

8

N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation.

Nirschl AA, Zou Y, Krystek SR Jr, Sutton JC, Simpkins LM, Lupisella JA, Kuhns JE, Seethala R, Golla R, Sleph PG, Beehler BC, Grover GJ, Egan D, Fura A, Vyas VP, Li YX, Sack JS, Kish KF, An Y, Bryson JA, Gougoutas JZ, DiMarco J, Zahler R, Ostrowski J, Hamann LG. Nirschl AA, et al. Among authors: gougoutas jz. J Med Chem. 2009 May 14;52(9):2794-8. doi: 10.1021/jm801583j. J Med Chem. 2009. PMID: 19351168

9

Conformational Switching and the Synthesis of Spiro[2H-indol]-3(1H)-ones by Radical Cyclization.

Sulsky R, Gougoutas JZ, DiMarco J, Biller SA. Sulsky R, et al. Among authors: gougoutas jz. J Org Chem. 1999 Jul 23;64(15):5504-5510. doi: 10.1021/jo970105t. J Org Chem. 1999. PMID: 11674614

10

Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.

Balog A, Rampulla R, Martin GS, Krystek SR, Attar R, Dell-John J, DiMarco JD, Fairfax D, Gougoutas J, Holst CL, Nation A, Rizzo C, Rossiter LM, Schweizer L, Shan W, Spergel S, Spires T, Cornelius G, Gottardis M, Trainor G, Vite GD, Salvati ME. Balog A, et al. ACS Med Chem Lett. 2015 Jun 19;6(8):908-12. doi: 10.1021/acsmedchemlett.5b00173. eCollection 2015 Aug 13. ACS Med Chem Lett. 2015. PMID: 26288692 Free PMC article.

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