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A novel long chain polyunsaturated fatty acid, beta-Oxa 21:3n-3, inhibits T lymphocyte proliferation, cytokine production, delayed-type hypersensitivity, and carrageenan-induced paw reaction and selectively targets intracellular signals.
Costabile M, Hii CS, Robinson BS, Rathjen DA, Pitt M, Easton C, Miller RC, Poulos A, Murray AW, Ferrante A. Costabile M, et al. Among authors: rathjen da. J Immunol. 2001 Oct 1;167(7):3980-7. doi: 10.4049/jimmunol.167.7.3980. J Immunol. 2001. PMID: 11564817
A novel beta-oxa polyunsaturated fatty acid downregulates the activation of the IkappaB kinase/nuclear factor kappaB pathway, inhibits expression of endothelial cell adhesion molecules, and depresses inflammation.
Ferrante A, Robinson BS, Singh H, Jersmann HP, Ferrante JV, Huang ZH, Trout NA, Pitt MJ, Rathjen DA, Easton CJ, Poulos A, Prager RH, Lee FS, Hii CS. Ferrante A, et al. Among authors: rathjen da. Circ Res. 2006 Jul 7;99(1):34-41. doi: 10.1161/01.RES.0000231292.66084.cd. Epub 2006 Jun 8. Circ Res. 2006. PMID: 16763165
Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Evidence for cell type-specific activation of mitogen-activated protein kinases.
Hii CS, Huang ZH, Bilney A, Costabile M, Murray AW, Rathjen DA, Der CJ, Ferrante A. Hii CS, et al. Among authors: rathjen da. J Biol Chem. 1998 Jul 24;273(30):19277-82. doi: 10.1074/jbc.273.30.19277. J Biol Chem. 1998. PMID: 9668117 Free article.
Altered responses of human macrophages to lipopolysaccharide by hydroperoxy eicosatetraenoic acid, hydroxy eicosatetraenoic acid, and arachidonic acid. Inhibition of tumor necrosis factor production.
Ferrante JV, Huang ZH, Nandoskar M, Hii CS, Robinson BS, Rathjen DA, Poulos A, Morris CP, Ferrante A. Ferrante JV, et al. Among authors: rathjen da. J Clin Invest. 1997 Mar 15;99(6):1445-52. doi: 10.1172/JCI119303. J Clin Invest. 1997. PMID: 9077554 Free PMC article.
38 results