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TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid.
McMillan IO, Liang L, Su G, Song X, Drago K, Yang H, Alvarez C, Sood A, Gibson J, Woods RJ, Wang C, Liu J, Zhang F, Brett TJ, Wang L. McMillan IO, et al. Among authors: brett tj. J Biol Chem. 2024 Sep;300(9):107691. doi: 10.1016/j.jbc.2024.107691. Epub 2024 Aug 17. J Biol Chem. 2024. PMID: 39159814 Free PMC article.
Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42.
Kober DL, Stuchell-Brereton MD, Kluender CE, Dean HB, Strickland MR, Steinberg DF, Nelson SS, Baban B, Holtzman DM, Frieden C, Alexander-Brett J, Roberson ED, Song Y, Brett TJ. Kober DL, et al. Among authors: brett tj. Alzheimers Dement. 2020 Oct 8:10.1002/alz.12194. doi: 10.1002/alz.12194. Online ahead of print. Alzheimers Dement. 2020. PMID: 33090700 Free PMC article.
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.
Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleo A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Ewers M, Harari O, Haass C, Brett TJ, Benitez BA, Karch CM, Piccio L, Cruchaga C. Deming Y, et al. Among authors: brett tj. Sci Transl Med. 2019 Aug 14;11(505):eaau2291. doi: 10.1126/scitranslmed.aau2291. Sci Transl Med. 2019. PMID: 31413141 Free PMC article.
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands.
Greven JA, Wydra JR, Greer RA, Zhi C, Camitta C, Song Y, Alexander-Brett JM, Brett TJ. Greven JA, et al. Among authors: brett tj. Res Sq [Preprint]. 2024 Sep 12:rs.3.rs-4850141. doi: 10.21203/rs.3.rs-4850141/v1. Res Sq. 2024. Update in: Mol Neurodegener. 2025 Jan 9;20(1):3. doi: 10.1186/s13024-024-00795-9 PMID: 39315272 Free PMC article. Updated. Preprint.
45 results