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Page 1
EmtA, a rRNA methyltransferase conferring high-level evernimicin resistance.
Mann PA, Xiong L, Mankin AS, Chau AS, Mendrick CA, Najarian DJ, Cramer CA, Loebenberg D, Coates E, Murgolo NJ, Aarestrup FM, Goering RV, Black TA, Hare RS, McNicholas PM. Mann PA, et al. Among authors: loebenberg d. Mol Microbiol. 2001 Sep;41(6):1349-56. doi: 10.1046/j.1365-2958.2001.02602.x. Mol Microbiol. 2001. PMID: 11580839 Free article.
Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase.
Mann PA, Parmegiani RM, Wei SQ, Mendrick CA, Li X, Loebenberg D, DiDomenico B, Hare RS, Walker SS, McNicholas PM. Mann PA, et al. Among authors: loebenberg d. Antimicrob Agents Chemother. 2003 Feb;47(2):577-81. doi: 10.1128/AAC.47.2.577-581.2003. Antimicrob Agents Chemother. 2003. PMID: 12543662 Free PMC article.
Changes in susceptibility to posaconazole in clinical isolates of Candida albicans.
Li X, Brown N, Chau AS, López-Ribot JL, Ruesga MT, Quindos G, Mendrick CA, Hare RS, Loebenberg D, DiDomenico B, McNicholas PM. Li X, et al. Among authors: loebenberg d. J Antimicrob Chemother. 2004 Jan;53(1):74-80. doi: 10.1093/jac/dkh027. Epub 2003 Dec 4. J Antimicrob Chemother. 2004. PMID: 14657086
Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.
Xiao L, Madison V, Chau AS, Loebenberg D, Palermo RE, McNicholas PM. Xiao L, et al. Among authors: loebenberg d. Antimicrob Agents Chemother. 2004 Feb;48(2):568-74. doi: 10.1128/AAC.48.2.568-574.2004. Antimicrob Agents Chemother. 2004. PMID: 14742211 Free PMC article.
In vitro uptake of SCH 27899 (evernimicin) by rat alveolar macrophages.
Zbaida S, Brieland J, Krieter P, Loebenberg D, Krishna G, Horne D, Lu X, Yuan Y, Hare R, Cayen MN, Patrick JE. Zbaida S, et al. Among authors: loebenberg d. Antimicrob Agents Chemother. 2001 Mar;45(3):959-61. doi: 10.1128/AAC.45.3.959-961.2001. Antimicrob Agents Chemother. 2001. PMID: 11181391 Free PMC article.
In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts.
Sabatelli F, Patel R, Mann PA, Mendrick CA, Norris CC, Hare R, Loebenberg D, Black TA, McNicholas PM. Sabatelli F, et al. Among authors: loebenberg d. Antimicrob Agents Chemother. 2006 Jun;50(6):2009-15. doi: 10.1128/AAC.00163-06. Antimicrob Agents Chemother. 2006. PMID: 16723559 Free PMC article.
Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds.
Munayyer HK, Mann PA, Chau AS, Yarosh-Tomaine T, Greene JR, Hare RS, Heimark L, Palermo RE, Loebenberg D, McNicholas PM. Munayyer HK, et al. Among authors: loebenberg d. Antimicrob Agents Chemother. 2004 Oct;48(10):3690-6. doi: 10.1128/AAC.48.10.3690-3696.2004. Antimicrob Agents Chemother. 2004. PMID: 15388421 Free PMC article.
102 results