Schmidt HH - Search Results

1

Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin.

Kotsonis P, Fröhlich LG, Raman CS, Li H, Berg M, Gerwig R, Groehn V, Kang Y, Al-Masoudi N, Taghavi-Moghadam S, Mohr D, Münch U, Schnabel J, Martásek P, Masters BS, Strobel H, Poulos T, Matter H, Pfleiderer W, Schmidt HH. Kotsonis P, et al. Among authors: schmidt hh. J Biol Chem. 2001 Dec 28;276(52):49133-41. doi: 10.1074/jbc.M011469200. Epub 2001 Oct 5. J Biol Chem. 2001. PMID: 11590164 Free article.

2

Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors.

Matter H, Kotsonis P, Klingler O, Strobel H, Fröhlich LG, Frey A, Pfleiderer W, Schmidt HH. Matter H, et al. Among authors: schmidt hh. J Med Chem. 2002 Jul 4;45(14):2923-41. doi: 10.1021/jm020074g. J Med Chem. 2002. PMID: 12086480

3

Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases.

Matter H, Kumar HS, Fedorov R, Frey A, Kotsonis P, Hartmann E, Fröhlich LG, Reif A, Pfleiderer W, Scheurer P, Ghosh DK, Schlichting I, Schmidt HH. Matter H, et al. Among authors: schmidt hh. J Med Chem. 2005 Jul 28;48(15):4783-92. doi: 10.1021/jm050007x. J Med Chem. 2005. PMID: 16033258

4

Anti-pterins as tools to characterize the function of tetrahydrobiopterin in NO synthase.

Bömmel HM, Reif A, Fröhlich LG, Frey A, Hofmann H, Marecak DM, Groehn V, Kotsonis P, La M, Köster S, Meinecke M, Bernhardt M, Weeger M, Ghisla S, Prestwich GD, Pfleiderer W, Schmidt HH. Bömmel HM, et al. Among authors: schmidt hh. J Biol Chem. 1998 Dec 11;273(50):33142-9. doi: 10.1074/jbc.273.50.33142. J Biol Chem. 1998. PMID: 9837881 Free article.

5

Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase.

Reif A, Fröhlich LG, Kotsonis P, Frey A, Bömmel HM, Wink DA, Pfleiderer W, Schmidt HH. Reif A, et al. Among authors: schmidt hh. J Biol Chem. 1999 Aug 27;274(35):24921-9. doi: 10.1074/jbc.274.35.24921. J Biol Chem. 1999. PMID: 10455167 Free article.

6

Inhibition of neuronal nitric oxide synthase by 4-amino pteridine derivatives: structure-activity relationship of antagonists of (6R)-5,6,7,8-tetrahydrobiopterin cofactor.

Fröhlich LG, Kotsonis P, Traub H, Taghavi-Moghadam S, Al-Masoudi N, Hofmann H, Strobel H, Matter H, Pfleiderer W, Schmidt HH. Fröhlich LG, et al. Among authors: schmidt hh. J Med Chem. 1999 Oct 7;42(20):4108-21. doi: 10.1021/jm981129a. J Med Chem. 1999. PMID: 10514281

7

Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases.

Butt E, Bernhardt M, Smolenski A, Kotsonis P, Fröhlich LG, Sickmann A, Meyer HE, Lohmann SM, Schmidt HH. Butt E, et al. Among authors: schmidt hh. J Biol Chem. 2000 Feb 18;275(7):5179-87. doi: 10.1074/jbc.275.7.5179. J Biol Chem. 2000. PMID: 10671564 Free article.

8

Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide.

Kotsonis P, Fröhlich LG, Shutenko ZV, Horejsi R, Pfleiderer W, Schmidt HH. Kotsonis P, et al. Among authors: schmidt hh. Biochem J. 2000 Mar 15;346 Pt 3(Pt 3):767-76. Biochem J. 2000. PMID: 10698705 Free PMC article.

9

Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity.

Kotsonis P, Frey A, Fröhlich LG, Hofmann H, Reif A, Wink DA, Feelisch M, Schmidt HH. Kotsonis P, et al. Among authors: schmidt hh. Biochem J. 1999 Jun 15;340 ( Pt 3)(Pt 3):745-52. Biochem J. 1999. PMID: 10359660 Free PMC article.

10

Pterin interactions with distinct reductase activities of NO synthase.

Pantke MM, Reif A, Valtschanoff JG, Shutenko Z, Frey A, Weinberg RJ, Pfleiderer W, Schmidt HH. Pantke MM, et al. Among authors: schmidt hh. Biochem J. 2001 May 15;356(Pt 1):43-51. doi: 10.1042/0264-6021:3560043. Biochem J. 2001. PMID: 11336634 Free PMC article.

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