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Administration of two macrophage-derived interferon-gamma-inducing factors (IL-12 and IL-15) induces a lethal systemic inflammatory response in mice that is dependent on natural killer cells but does not require interferon-gamma.
Biber JL, Jabbour S, Parihar R, Dierksheide J, Hu Y, Baumann H, Bouchard P, Caligiuri MA, Carson W. Biber JL, et al. Among authors: dierksheide j. Cell Immunol. 2002 Mar-Apr;216(1-2):31-42. doi: 10.1016/s0008-8749(02)00501-4. Cell Immunol. 2002. PMID: 12381348
Coadministration of interleukin-18 and interleukin-12 induces a fatal inflammatory response in mice: critical role of natural killer cell interferon-gamma production and STAT-mediated signal transduction.
Carson WE, Dierksheide JE, Jabbour S, Anghelina M, Bouchard P, Ku G, Yu H, Baumann H, Shah MH, Cooper MA, Durbin J, Caligiuri MA. Carson WE, et al. Among authors: dierksheide je. Blood. 2000 Aug 15;96(4):1465-73. Blood. 2000. PMID: 10942393 Free article.
A phase I study of interleukin 12 with trastuzumab in patients with human epidermal growth factor receptor-2-overexpressing malignancies: analysis of sustained interferon gamma production in a subset of patients.
Parihar R, Nadella P, Lewis A, Jensen R, De Hoff C, Dierksheide JE, VanBuskirk AM, Magro CM, Young DC, Shapiro CL, Carson WE 3rd. Parihar R, et al. Among authors: dierksheide je. Clin Cancer Res. 2004 Aug 1;10(15):5027-37. doi: 10.1158/1078-0432.CCR-04-0265. Clin Cancer Res. 2004. PMID: 15297404 Clinical Trial.
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