Broomfield CA - Search Results

1

Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality.

Duysen EG, Li B, Xie W, Schopfer LM, Anderson RS, Broomfield CA, Lockridge O. Duysen EG, et al. Among authors: broomfield ca. J Pharmacol Exp Ther. 2001 Nov;299(2):528-35. J Pharmacol Exp Ther. 2001. PMID: 11602663

2

A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters.

Masson P, Nachon F, Broomfield CA, Lenz DE, Verdier L, Schopfer LM, Lockridge O. Masson P, et al. Among authors: broomfield ca. Chem Biol Interact. 2008 Sep 25;175(1-3):273-80. doi: 10.1016/j.cbi.2008.04.005. Epub 2008 Apr 16. Chem Biol Interact. 2008. PMID: 18508040

3

A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase.

Lockridge O, Blong RM, Masson P, Froment MT, Millard CB, Broomfield CA. Lockridge O, et al. Among authors: broomfield ca. Biochemistry. 1997 Jan 28;36(4):786-95. doi: 10.1021/bi961412g. Biochemistry. 1997. PMID: 9020776

4

Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization.

Broomfield CA, Lockridge O, Millard CB. Broomfield CA, et al. Chem Biol Interact. 1999 May 14;119-120:413-8. doi: 10.1016/s0009-2797(99)00053-8. Chem Biol Interact. 1999. PMID: 10421478

5

Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase.

Millard CB, Lockridge O, Broomfield CA. Millard CB, et al. Among authors: broomfield ca. Biochemistry. 1998 Jan 6;37(1):237-47. doi: 10.1021/bi972057c. Biochemistry. 1998. PMID: 9425044

6

Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase.

Millard CB, Lockridge O, Broomfield CA. Millard CB, et al. Among authors: broomfield ca. Biochemistry. 1995 Dec 12;34(49):15925-33. doi: 10.1021/bi00049a007. Biochemistry. 1995. PMID: 8519749

7

Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates.

Broomfield CA, Maxwell DM, Solana RP, Castro CA, Finger AV, Lenz DE. Broomfield CA, et al. J Pharmacol Exp Ther. 1991 Nov;259(2):633-8. J Pharmacol Exp Ther. 1991. PMID: 1941611

8

A purified recombinant organophosphorus acid anhydrase protects mice against soman.

Broomfield CA. Broomfield CA. Pharmacol Toxicol. 1992 Jan;70(1):65-6. doi: 10.1111/j.1600-0773.1992.tb00429.x. Pharmacol Toxicol. 1992. PMID: 1317565

9

Catalytic antibodies hydrolysing organophosphorus esters.

Brimfield AA, Lenz DE, Maxwell DM, Broomfield CA. Brimfield AA, et al. Among authors: broomfield ca. Chem Biol Interact. 1993 Jun;87(1-3):95-102. doi: 10.1016/0009-2797(93)90029-x. Chem Biol Interact. 1993. PMID: 8344006

10

Comparison of human and guinea pig acetylcholinesterase sequences and rates of oxime-assisted reactivation.

Cadieux CL, Broomfield CA, Kirkpatrick MG, Kazanski ME, Lenz DE, Cerasoli DM. Cadieux CL, et al. Among authors: broomfield ca. Chem Biol Interact. 2010 Sep 6;187(1-3):229-33. doi: 10.1016/j.cbi.2010.04.020. Epub 2010 Apr 28. Chem Biol Interact. 2010. PMID: 20433814

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