Larsen SD - Search Results

1

Cyclopentene Synthesis from 1,3-Dienes via Base-Induced Ring Contraction of 3,6-Dihydro-2H-thiopyrans: Studies on Diastereoselection and Mechanism.

Larsen SD, Fisher PV, Libby BE, Jensen RM, Mizsak SA, Watt W, Ronk WR, Hill ST. Larsen SD, et al. J Org Chem. 1996 Jul 12;61(14):4725-4738. doi: 10.1021/jo960537o. J Org Chem. 1996. PMID: 11667404

2

Synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid antidiabetic agent.

Larsen SD, Connell MA, Cudahy MM, Evans BR, May PD, Meglasson MD, O'Sullivan TJ, Schostarez HJ, Sih JC, Stevens FC, Tanis SP, Tegley CM, Tucker JA, Vaillancourt VA, Vidmar TJ, Watt W, Yu JH. Larsen SD, et al. J Med Chem. 2001 Apr 12;44(8):1217-30. doi: 10.1021/jm000095f. J Med Chem. 2001. PMID: 11312922

3

Synthesis and biological activity of aminoguanidine and diaminoguanidine analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid.

Vaillancourt VA, Larsen SD, Tanis SP, Burr JE, Connell MA, Cudahy MM, Evans BR, Fisher PV, May PD, Meglasson MD, Robinson DD, Stevens FC, Tucker JA, Vidmar TJ, Yu JH. Vaillancourt VA, et al. Among authors: larsen sd. J Med Chem. 2001 Apr 12;44(8):1231-48. doi: 10.1021/jm000094n. J Med Chem. 2001. PMID: 11312923

4

Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway.

Bell JL, Haak AJ, Wade SM, Sun Y, Neubig RR, Larsen SD. Bell JL, et al. Among authors: larsen sd. Beilstein J Org Chem. 2013 May 21;9:966-73. doi: 10.3762/bjoc.9.111. Print 2013. Beilstein J Org Chem. 2013. PMID: 23766813 Free PMC article.

5

Synthesis and hypocholesterolemic activity of 6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-diones, novel inhibitors of acylCoA:cholesterol O-acyltransferase.

Larsen SD, Spilman CH, Bell FP, Dinh DM, Martinborough E, Wilson GJ. Larsen SD, et al. J Med Chem. 1991 May;34(5):1721-7. doi: 10.1021/jm00109a028. J Med Chem. 1991. PMID: 2033594

6

Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B.

Larsen SD, Barf T, Liljebris C, May PD, Ogg D, O'Sullivan TJ, Palazuk BJ, Schostarez HJ, Stevens FC, Bleasdale JE. Larsen SD, et al. J Med Chem. 2002 Jan 31;45(3):598-622. doi: 10.1021/jm010393s. J Med Chem. 2002. PMID: 11806712

7

Novel inhibitors of neurotropic alphavirus replication that improve host survival in a mouse model of acute viral encephalitis.

Sindac JA, Yestrepsky BD, Barraza SJ, Bolduc KL, Blakely PK, Keep RF, Irani DN, Miller DJ, Larsen SD. Sindac JA, et al. Among authors: larsen sd. J Med Chem. 2012 Apr 12;55(7):3535-45. doi: 10.1021/jm300214e. Epub 2012 Apr 3. J Med Chem. 2012. PMID: 22428985 Free PMC article.

8

Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor.

Homan KT, Waldschmidt HV, Glukhova A, Cannavo A, Song J, Cheung JY, Koch WJ, Larsen SD, Tesmer JJG. Homan KT, et al. Among authors: larsen sd. J Biol Chem. 2015 Aug 21;290(34):20649-20659. doi: 10.1074/jbc.M115.647370. Epub 2015 Jun 1. J Biol Chem. 2015. PMID: 26032411 Free PMC article.

9

Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy.

Huddle BC, Grimley E, Chtcherbinine M, Buchman CD, Takahashi C, Debnath B, McGonigal SC, Mao S, Li S, Felton J, Pan S, Wen B, Sun D, Neamati N, Buckanovich RJ, Hurley TD, Larsen SD. Huddle BC, et al. Among authors: larsen sd. Eur J Med Chem. 2021 Feb 5;211:113060. doi: 10.1016/j.ejmech.2020.113060. Epub 2020 Dec 3. Eur J Med Chem. 2021. PMID: 33341649 Free PMC article.

10

Design and synthesis of seco-oxysterol analogs as potential inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase gene transcription.

Larsen SD, Spilman CH, Yagi Y, Dinh DM, Hart KL, Hess GF. Larsen SD, et al. J Med Chem. 1994 Jul 22;37(15):2343-51. doi: 10.1021/jm00041a013. J Med Chem. 1994. PMID: 8057282

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