Hegmans A - Search Results

1

Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum-spermidine species through hydrolytic cleavage of carbamates.

Hegmans A, Qu Y, Kelland LR, Roberts JD, Farrell N. Hegmans A, et al. Inorg Chem. 2001 Nov 19;40(24):6108-14. doi: 10.1021/ic010509a. Inorg Chem. 2001. PMID: 11703107

2

Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge.

Harris AL, Yang X, Hegmans A, Povirk L, Ryan JJ, Kelland L, Farrell NP. Harris AL, et al. Among authors: hegmans a. Inorg Chem. 2005 Dec 26;44(26):9598-600. doi: 10.1021/ic051390z. Inorg Chem. 2005. PMID: 16363817

3

Kinetic and equilibria studies of the aquation of the trinuclear platinum phase II anticancer agent [(trans-PtCl(NH(3))(2))(2)(mu-trans-Pt(NH(3))(2)(NH(2)(CH(2))(6)NH(2))(2))](4+) (BBR3464).

Davies MS, Thomas DS, Hegmans A, Berners-Price SJ, Farrell N. Davies MS, et al. Among authors: hegmans a. Inorg Chem. 2002 Mar 11;41(5):1101-9. doi: 10.1021/ic010851n. Inorg Chem. 2002. PMID: 11874344

4

A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464.

McGregor TD, Hegmans A, Kaspárková J, Neplechová K, Nováková O, Penazová H, Vrána O, Brabec V, Farrell N. McGregor TD, et al. Among authors: hegmans a. J Biol Inorg Chem. 2002 Apr;7(4-5):397-404. doi: 10.1007/s00775-001-0312-4. Epub 2002 Jan 8. J Biol Inorg Chem. 2002. PMID: 11941497

5

Synthesis and DNA conformational changes of non-covalent polynuclear platinum complexes.

Qu Y, Harris A, Hegmans A, Petz A, Kabolizadeh P, Penazova H, Farrell N. Qu Y, et al. Among authors: hegmans a. J Inorg Biochem. 2004 Oct;98(10):1591-8. doi: 10.1016/j.jinorgbio.2004.07.012. J Inorg Biochem. 2004. PMID: 15458821

6

A surprisingly stable macrochelate formed from the reaction of cis dinuclear platinum antitumor compounds with reduced glutathione.

Oehlsen ME, Hegmans A, Qu Y, Farrell N. Oehlsen ME, et al. Among authors: hegmans a. Inorg Chem. 2005 May 2;44(9):3004-6. doi: 10.1021/ic0501972. Inorg Chem. 2005. PMID: 15847402

7

Effects of geometric isomerism in dinuclear antitumor platinum complexes on their interactions with N-acetyl-L-methionine.

Oehlsen ME, Hegmans A, Qu Y, Farrell N. Oehlsen ME, et al. Among authors: hegmans a. J Biol Inorg Chem. 2005 Aug;10(5):433-42. doi: 10.1007/s00775-005-0009-1. Epub 2005 Sep 23. J Biol Inorg Chem. 2005. PMID: 16091934

8

Amide-based prodrugs of spermidine-bridged dinuclear platinum. Synthesis, DNA binding, and biological activity.

Hegmans A, Kasparkova J, Vrana O, Kelland LR, Brabec V, Farrell NP. Hegmans A, et al. J Med Chem. 2008 Apr 10;51(7):2254-60. doi: 10.1021/jm070813z. Epub 2008 Mar 14. J Med Chem. 2008. PMID: 18338842 Free PMC article.

9

Long range 1,4 and 1,6-interstrand cross-links formed by a trinuclear platinum complex. Minor groove preassociation affects kinetics and mechanism of cross-link formation as well as adduct structure.

Hegmans A, Berners-Price SJ, Davies MS, Thomas DS, Humphreys AS, Farrell N. Hegmans A, et al. J Am Chem Soc. 2004 Feb 25;126(7):2166-80. doi: 10.1021/ja036105u. J Am Chem Soc. 2004. PMID: 14971952

10

Synthetic Ways to Tris(nucleobase) Complexes Derived from cis-Diammineplatinum(II) and a Platinum(II) Complex Containing Four Different Ligands, Three of Which Are Nucleobases.

Hegmans A, Sabat M, Baxter I, Freisinger E, Lippert B. Hegmans A, et al. Inorg Chem. 1998 Sep 21;37(19):4921-4928. doi: 10.1021/ic9802193. Inorg Chem. 1998. PMID: 11670657

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

13 results

Search Page

Filters