Wozniak K - Search Results

1

Design and pharmacological activity of phosphinic acid based NAALADase inhibitors.

Jackson PF, Tays KL, Maclin KM, Ko YS, Li W, Vitharana D, Tsukamoto T, Stoermer D, Lu XC, Wozniak K, Slusher BS. Jackson PF, et al. Among authors: wozniak k. J Med Chem. 2001 Nov 22;44(24):4170-5. doi: 10.1021/jm0001774. J Med Chem. 2001. PMID: 11708918

2

Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.

Majer P, Jackson PF, Delahanty G, Grella BS, Ko YS, Li W, Liu Q, Maclin KM, Poláková J, Shaffer KA, Stoermer D, Vitharana D, Wang EY, Zakrzewski A, Rojas C, Slusher BS, Wozniak KM, Burak E, Limsakun T, Tsukamoto T. Majer P, et al. J Med Chem. 2003 May 8;46(10):1989-96. doi: 10.1021/jm020515w. J Med Chem. 2003. PMID: 12723961

3

Enantiospecificity of glutamate carboxypeptidase II inhibition.

Tsukamoto T, Majer P, Vitharana D, Ni C, Hin B, Lu XC, Thomas AG, Wozniak KM, Calvin DC, Wu Y, Slusher BS, Scarpetti D, Bonneville GW. Tsukamoto T, et al. J Med Chem. 2005 Apr 7;48(7):2319-24. doi: 10.1021/jm049258g. J Med Chem. 2005. PMID: 15801825

4

Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain.

Majer P, Hin B, Stoermer D, Adams J, Xu W, Duvall BR, Delahanty G, Liu Q, Stathis MJ, Wozniak KM, Slusher BS, Tsukamoto T. Majer P, et al. J Med Chem. 2006 May 18;49(10):2876-85. doi: 10.1021/jm051019l. J Med Chem. 2006. PMID: 16686531

5

Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy.

Thomas AG, Wozniak KM, Tsukamoto T, Calvin D, Wu Y, Rojas C, Vornov J, Slusher BS. Thomas AG, et al. Adv Exp Med Biol. 2006;576:327-37; discussion 361-3. doi: 10.1007/0-387-30172-0_24. Adv Exp Med Biol. 2006. PMID: 16802724 Review.

6

Design, synthesis, and pharmacological evaluation of glutamate carboxypeptidase II (GCPII) inhibitors based on thioalkylbenzoic acid scaffolds.

Stoermer D, Vitharana D, Hin N, Delahanty G, Duvall B, Ferraris DV, Grella BS, Hoover R, Rojas C, Shanholtz MK, Smith KP, Stathis M, Wu Y, Wozniak KM, Slusher BS, Tsukamoto T. Stoermer D, et al. Among authors: wozniak km. J Med Chem. 2012 Jun 28;55(12):5922-32. doi: 10.1021/jm300488m. Epub 2012 Jun 12. J Med Chem. 2012. PMID: 22642259

7

δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors.

Ferraris DV, Majer P, Ni C, Slusher CE, Rais R, Wu Y, Wozniak KM, Alt J, Rojas C, Slusher BS, Tsukamoto T. Ferraris DV, et al. J Med Chem. 2014 Jan 9;57(1):243-7. doi: 10.1021/jm401703a. Epub 2013 Dec 27. J Med Chem. 2014. PMID: 24354364 Free PMC article.

8

Blockade of NAALADase: a novel neuroprotective strategy based on limiting glutamate and elevating NAAG.

Vornov JJ, Wozniak K, Lu M, Jackson P, Tsukamoto T, Wang E, Slusher B. Vornov JJ, et al. Among authors: wozniak k. Ann N Y Acad Sci. 1999;890:400-5. doi: 10.1111/j.1749-6632.1999.tb08019.x. Ann N Y Acad Sci. 1999. PMID: 10668445

9

Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury.

Slusher BS, Vornov JJ, Thomas AG, Hurn PD, Harukuni I, Bhardwaj A, Traystman RJ, Robinson MB, Britton P, Lu XC, Tortella FC, Wozniak KM, Yudkoff M, Potter BM, Jackson PF. Slusher BS, et al. Among authors: wozniak km. Nat Med. 1999 Dec;5(12):1396-402. doi: 10.1038/70971. Nat Med. 1999. PMID: 10581082

10

Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA).

Majer P, Jančařík A, Krečmerová M, Tichý T, Tenora L, Wozniak K, Wu Y, Pommier E, Ferraris D, Rais R, Slusher BS. Majer P, et al. Among authors: wozniak k. J Med Chem. 2016 Mar 24;59(6):2810-9. doi: 10.1021/acs.jmedchem.6b00062. Epub 2016 Mar 10. J Med Chem. 2016. PMID: 26930119

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