Sigal N - Search Results

1

Mapping of functional domains in the p22(phox) subunit of flavocytochrome b(559) participating in the assembly of the NADPH oxidase complex by "peptide walking".

Dahan I, Issaeva I, Gorzalczany Y, Sigal N, Hirshberg M, Pick E. Dahan I, et al. Among authors: sigal n. J Biol Chem. 2002 Mar 8;277(10):8421-32. doi: 10.1074/jbc.M109778200. Epub 2001 Dec 3. J Biol Chem. 2002. PMID: 11733522 Free article.

2

A prenylated p67phox-Rac1 chimera elicits NADPH-dependent superoxide production by phagocyte membranes in the absence of an activator and of p47phox: conversion of a pagan NADPH oxidase to monotheism.

Gorzalczany Y, Alloul N, Sigal N, Weinbaum C, Pick E. Gorzalczany Y, et al. Among authors: sigal n. J Biol Chem. 2002 May 24;277(21):18605-10. doi: 10.1074/jbc.M202114200. Epub 2002 Mar 14. J Biol Chem. 2002. PMID: 11896062 Free article.

3

The guanine nucleotide exchange factor trio activates the phagocyte NADPH oxidase in the absence of GDP to GTP exchange on Rac. "The emperor's nw clothes".

Sigal N, Gorzalczany Y, Sarfstein R, Weinbaum C, Zheng Y, Pick E. Sigal N, et al. J Biol Chem. 2003 Feb 14;278(7):4854-61. doi: 10.1074/jbc.M211011200. Epub 2002 Dec 9. J Biol Chem. 2003. PMID: 12475976 Free article.

4

Two pathways of activation of the superoxide-generating NADPH oxidase of phagocytes in vitro--distinctive effects of inhibitors.

Sigal N, Gorzalczany Y, Pick E. Sigal N, et al. Inflammation. 2003 Jun;27(3):147-59. doi: 10.1023/a:1023869828688. Inflammation. 2003. PMID: 12875368

5

Targeting of Rac1 to the phagocyte membrane is sufficient for the induction of NADPH oxidase assembly.

Gorzalczany Y, Sigal N, Itan M, Lotan O, Pick E. Gorzalczany Y, et al. Among authors: sigal n. J Biol Chem. 2000 Dec 22;275(51):40073-81. doi: 10.1074/jbc.M006013200. J Biol Chem. 2000. PMID: 11007780 Free article.

6

Activation of the superoxide-generating NADPH oxidase by chimeric proteins consisting of segments of the cytosolic component p67(phox) and the small GTPase Rac1.

Alloul N, Gorzalczany Y, Itan M, Sigal N, Pick E. Alloul N, et al. Among authors: sigal n. Biochemistry. 2001 Dec 4;40(48):14557-66. doi: 10.1021/bi0117347. Biochemistry. 2001. PMID: 11724569

7

Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients.

Pickering H, Schaenman J, Phan HV, Maguire C, Tsitsiklis A, Rouphael N, Higuita NIA, Atkinson MA, Brakenridge S, Fung M, Messer W; IMPACC Network; Salehi-Rad R, Altman MC, Becker PM, Bosinger SE, Eckalbar W, Hoch A, Doni Jayavelu N, Kim-Schulze S, Jenkins M, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Diray-Arce J, Shaw A, Baden L, Levy O, Reed EF, Langelier CR. Pickering H, et al. Nat Commun. 2025 Jan 10;16(1):586. doi: 10.1038/s41467-025-55823-z. Nat Commun. 2025. PMID: 39794319 Free PMC article.

8

Specialized Listeria monocytogenes produce tailocins to provide a population-level competitive growth advantage.

Sigal N, Lichtenstein-Wolfheim R, Schlussel S, Azulay G, Borovok I, Holdengraber V, Elad N, Wolf SG, Zalk R, Zarivach R, Frank GA, Herskovits AA. Sigal N, et al. Nat Microbiol. 2024 Oct;9(10):2727-2737. doi: 10.1038/s41564-024-01793-9. Epub 2024 Sep 19. Nat Microbiol. 2024. PMID: 39300324

9

Single-cell peripheral immunoprofiling of lewy body and Parkinson's disease in a multi-site cohort.

Phongpreecha T, Mathi K, Cholerton B, Fox EJ, Sigal N, Espinosa C, Reincke M, Chung P, Hwang LJ, Gajera CR, Berson E, Perna A, Xie F, Shu CH, Hazra D, Channappa D, Dunn JE, Kipp LB, Poston KL, Montine KS, Maecker HT, Aghaeepour N, Montine TJ. Phongpreecha T, et al. Among authors: sigal n. Mol Neurodegener. 2024 Aug 1;19(1):59. doi: 10.1186/s13024-024-00748-2. Mol Neurodegener. 2024. PMID: 39090623 Free PMC article.

10

Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology.

Phan HV, Tsitsiklis A, Maguire CP, Haddad EK, Becker PM, Kim-Schulze S, Lee B, Chen J, Hoch A, Pickering H, van Zalm P, Altman MC, Augustine AD, Calfee CS, Bosinger S, Cairns CB, Eckalbar W, Guan L, Jayavelu ND, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Peters B, Rouphael N; IMPACC Network; Montgomery RR, Reed E, Schaenman J, Steen H, Levy O, Diray-Arce J, Langelier CR. Phan HV, et al. Sci Transl Med. 2024 Apr 17;16(743):eadj5154. doi: 10.1126/scitranslmed.adj5154. Epub 2024 Apr 17. Sci Transl Med. 2024. PMID: 38630846

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