Hayashi K - Search Results

1

A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues.

Honma T, Yoshizumi T, Hashimoto N, Hayashi K, Kawanishi N, Fukasawa K, Takaki T, Ikeura C, Ikuta M, Suzuki-Takahashi I, Hayama T, Nishimura S, Morishima H. Honma T, et al. Among authors: hayashi k. J Med Chem. 2001 Dec 20;44(26):4628-40. doi: 10.1021/jm010326y. J Med Chem. 2001. PMID: 11741480

2

Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design.

Honma T, Hayashi K, Aoyama T, Hashimoto N, Machida T, Fukasawa K, Iwama T, Ikeura C, Ikuta M, Suzuki-Takahashi I, Iwasawa Y, Hayama T, Nishimura S, Morishima H. Honma T, et al. Among authors: hayashi k. J Med Chem. 2001 Dec 20;44(26):4615-27. doi: 10.1021/jm0103256. J Med Chem. 2001. PMID: 11741479

3

Novel angiotensin II receptor antagonists. Design, synthesis, and in vitro evaluation of dibenzo[a,d]cycloheptene and dibenzo[b,f]oxepin derivatives. Searching for bioisosteres of biphenylyltetrazole using a three-dimensional search technique.

Kiyama R, Honma T, Hayashi K, Ogawa M, Hara M, Fujimoto M, Fujishita T. Kiyama R, et al. Among authors: hayashi k. J Med Chem. 1995 Jul 7;38(14):2728-41. doi: 10.1021/jm00014a024. J Med Chem. 1995. PMID: 7629811

4

Synthesis and structure-activity relationship of a new series of potent angiotensin II receptor antagonists: pyrazolo[1,5-a]pyrimidine derivatives.

Shiota T, Yamamori T, Sakai K, Kiyokawa M, Honma T, Ogawa M, Hayashi K, Ishizuka N, Matsumura K, Hara M, Fujimoto M, Kawabata T, Nakajima S. Shiota T, et al. Among authors: hayashi k. Chem Pharm Bull (Tokyo). 1999 Jul;47(7):928-38. doi: 10.1248/cpb.47.928. Chem Pharm Bull (Tokyo). 1999. PMID: 10434395

5

Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity.

Kimura T, Takase Y, Hayashi K, Tanaka H, Ohtsuka I, Saeki T, Kogushi M, Yamada T, Fujimori T, Saitou I, et al. Kimura T, et al. Among authors: hayashi k. J Med Chem. 1993 May 28;36(11):1630-40. doi: 10.1021/jm00063a013. J Med Chem. 1993. PMID: 8496930

6

Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2.

Kimura T, Watanabe N, Matsui M, Hayashi K, Tanaka H, Ohtsuka I, Saeki T, Kogushi M, Kabayashi H, Akasaka K, et al. Kimura T, et al. Among authors: hayashi k. J Med Chem. 1993 May 28;36(11):1641-53. doi: 10.1021/jm00063a014. J Med Chem. 1993. PMID: 8496931

7

Renin inhibitor: relationship between molecular structure and oral absorption.

Hashimoto N, Fujioka T, Hayashi K, Odaguchi K, Toyoda T, Nakamura M, Hirano K. Hashimoto N, et al. Among authors: hayashi k. Pharm Res. 1994 Oct;11(10):1443-7. doi: 10.1023/a:1018948007419. Pharm Res. 1994. PMID: 7855049

8

Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives.

Hayashi K, Nunami K, Kato J, Yoneda N, Kubo M, Ochiai T, Ishida R. Hayashi K, et al. J Med Chem. 1989 Feb;32(2):289-97. doi: 10.1021/jm00122a003. J Med Chem. 1989. PMID: 2913292

9

Ototoxicity: mechanisms of cochlear impairment and its prevention.

Tabuchi K, Nishimura B, Nakamagoe M, Hayashi K, Nakayama M, Hara A. Tabuchi K, et al. Among authors: hayashi k. Curr Med Chem. 2011;18(31):4866-71. doi: 10.2174/092986711797535254. Curr Med Chem. 2011. PMID: 21919841 Review.

10

Synthesis of a chitosan tetramer derivative, beta-D-GlcNAc-(1-->4)-beta-D-GlcNAc-(1-->4)-beta-D-GlcNAc-(1-->4)-D-Glc N through a partial N-acetylation reaction by chitin deacetylase.

Tokuyasu K, Ono H, Mitsutomi M, Hayashi K, Mori Y. Tokuyasu K, et al. Among authors: hayashi k. Carbohydr Res. 2000 Apr 20;325(3):211-5. doi: 10.1016/s0008-6215(00)00004-5. Carbohydr Res. 2000. PMID: 10795812

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