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Page 1
Specific and dual antagonists of alpha(4)beta(1) and alpha(4)beta(7) integrins.
Lin LS, Lanza T Jr, McCauley E, Van Riper G, Kidambi U, Cao J, Egger LA, Mumford RA, Schmidt JA, MacCoss M, Hagmann WK. Lin LS, et al. Among authors: egger la. Bioorg Med Chem Lett. 2002 Jan 21;12(2):133-6. doi: 10.1016/s0960-894x(01)00705-3. Bioorg Med Chem Lett. 2002. PMID: 11755338
The discovery of acylated beta-amino acids as potent and orally bioavailable VLA-4 antagonists.
Lin LS, Kopka IE, Mumford RA, Magriotis PA, Lanza T Jr, Durette PL, Kamenecka T, Young DN, de Laszlo SE, McCauley E, Riper GV, Kidambi U, Egger LA, Tong X, Lyons K, Vincent S, Stearns R, Colletti A, Teffera Y, Fenyk-Melody J, Schmidt JA, MacCoss M, Hagmann WK. Lin LS, et al. Among authors: egger la. Bioorg Med Chem Lett. 2002 Feb 25;12(4):611-4. doi: 10.1016/s0960-894x(01)00818-6. Bioorg Med Chem Lett. 2002. PMID: 11844683
N-Tetrahydrofuroyl-(L)-phenylalanine derivatives as potent VLA-4 antagonists.
Yang GX, Chang LL, Truong Q, Doherty GA, Magriotis PA, de Laszlo SE, Li B, MacCoss M, Kidambi U, Egger LA, McCauley E, Van Riper G, Mumford RA, Schmidt JA, Hagmann WK. Yang GX, et al. Among authors: egger la. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1497-500. doi: 10.1016/s0960-894x(02)00210-x. Bioorg Med Chem Lett. 2002. PMID: 12031328
Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow.
Egger LA, Kidambi U, Cao J, Van Riper G, McCauley E, Mumford RA, Amo S, Lingham R, Lanza T, Lin LS, De Laszlo SE, Young DN, Kopka IE, Tong S, Pikounis B, Benson E, Warwood S, Bargatze RF, Hagmann WK, Schmidt JA, Detmers PA. Egger LA, et al. J Pharmacol Exp Ther. 2002 Jul;302(1):153-62. doi: 10.1124/jpet.302.1.153. J Pharmacol Exp Ther. 2002. PMID: 12065712
N-aryl-prolyl-dipeptides as potent antagonists of VLA-4.
Kamenecka TM, Lanza T Jr, de Laszlo SE, Li B, McCauley ED, Van Riper G, Egger LA, Kidambi U, Mumford RA, Tong S, MacCoss M, Schmidt JA, Hagmann WK. Kamenecka TM, et al. Among authors: egger la. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2205-8. doi: 10.1016/s0960-894x(02)00356-6. Bioorg Med Chem Lett. 2002. PMID: 12127538
Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.
Kopka IE, Lin LS, Mumford RA, Lanza T Jr, Magriotis PA, Young D, DeLaszlo SE, MacCoss M, Mills SG, Van Riper G, McCauley E, Lyons K, Vincent S, Egger LA, Kidambi U, Stearns R, Colletti A, Teffera Y, Tong S, Owens K, Levorse D, Schmidt JA, Hagmann WK. Kopka IE, et al. Among authors: egger la. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2415-8. doi: 10.1016/s0960-894x(02)00460-2. Bioorg Med Chem Lett. 2002. PMID: 12161146
A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence.
Egger LA, Cao J, McCallum C, Kidambi U, Van Riper G, McCauley E, Mumford RA, Lanza TJ, Lin LS, de Laszlo SE, Young DN, Yang G, Dean DC, Raab CE, Wallace MA, Jones AN, Hagmann WK, Schmidt JA, Pepinsky RB, Scott DM, Lee WC, Cornebise MA, Detmers PA. Egger LA, et al. J Pharmacol Exp Ther. 2003 Sep;306(3):903-13. doi: 10.1124/jpet.102.047704. Epub 2003 May 23. J Pharmacol Exp Ther. 2003. PMID: 12766251
23 results