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896 results

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Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia.
Dinchuk JE, Focht RJ, Kelley JA, Henderson NL, Zolotarjova NI, Wynn R, Neff NT, Link J, Huber RM, Burn TC, Rupar MJ, Cunningham MR, Selling BH, Ma J, Stern AA, Hollis GF, Stein RB, Friedman PA. Dinchuk JE, et al. Among authors: wynn r. J Biol Chem. 2002 Apr 12;277(15):12970-7. doi: 10.1074/jbc.M110389200. Epub 2001 Dec 31. J Biol Chem. 2002. PMID: 11773073 Free article.
Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics.
Ala PJ, Gonneville L, Hillman MC, Becker-Pasha M, Wei M, Reid BG, Klabe R, Yue EW, Wayland B, Douty B, Polam P, Wasserman Z, Bower M, Combs AP, Burn TC, Hollis GF, Wynn R. Ala PJ, et al. Among authors: wynn r. J Biol Chem. 2006 Oct 27;281(43):32784-95. doi: 10.1074/jbc.M606873200. Epub 2006 Aug 17. J Biol Chem. 2006. PMID: 16916797 Free article.
Structural insights into the design of nonpeptidic isothiazolidinone-containing inhibitors of protein-tyrosine phosphatase 1B.
Ala PJ, Gonneville L, Hillman M, Becker-Pasha M, Yue EW, Douty B, Wayland B, Polam P, Crawley ML, McLaughlin E, Sparks RB, Glass B, Takvorian A, Combs AP, Burn TC, Hollis GF, Wynn R. Ala PJ, et al. Among authors: wynn r. J Biol Chem. 2006 Dec 8;281(49):38013-21. doi: 10.1074/jbc.M607913200. Epub 2006 Oct 6. J Biol Chem. 2006. PMID: 17028182 Free article.
Large-scale purification of active platelet integrin glycoprotein IIb-IIIa.
Hillman MC, Zolotarjova NI, Patrick DR, McCabe DD, Shen K, Corman JI, Billheimer JT, Seiffert DA, Hollis GF, Wynn R. Hillman MC, et al. Among authors: wynn r. Protein Expr Purif. 2002 Aug;25(3):494-502. doi: 10.1016/s1046-5928(02)00027-x. Protein Expr Purif. 2002. PMID: 12182831
Evidence that thrombocytopenia observed in humans treated with orally bioavailable glycoprotein IIb/IIIa antagonists is immune mediated.
Billheimer JT, Dicker IB, Wynn R, Bradley JD, Cromley DA, Godonis HE, Grimminger LC, He B, Kieras CJ, Pedicord DL, Spitz SM, Thomas BE, Zolotarjova NI, Gorko MA, Hollis GF, Daly RN, Stern AM, Seiffert D. Billheimer JT, et al. Among authors: wynn r. Blood. 2002 May 15;99(10):3540-6. doi: 10.1182/blood.v99.10.3540. Blood. 2002. PMID: 11986205 Free article.
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
Yao W, Zhuo J, Burns DM, Xu M, Zhang C, Li YL, Qian DQ, He C, Weng L, Shi E, Lin Q, Agrios C, Burn TC, Caulder E, Covington MB, Fridman JS, Friedman S, Katiyar K, Hollis G, Li Y, Liu C, Liu X, Marando CA, Newton R, Pan M, Scherle P, Taylor N, Vaddi K, Wasserman ZR, Wynn R, Yeleswaram S, Jalluri R, Bower M, Zhou BB, Metcalf B. Yao W, et al. Among authors: wynn r. J Med Chem. 2007 Feb 22;50(4):603-6. doi: 10.1021/jm061344o. Epub 2007 Jan 26. J Med Chem. 2007. PMID: 17256836
896 results