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Pneumolysin causes neuronal cell death through mitochondrial damage.
Braun JS, Hoffmann O, Schickhaus M, Freyer D, Dagand E, Bermpohl D, Mitchell TJ, Bechmann I, Weber JR. Braun JS, et al. Among authors: mitchell tj. Infect Immun. 2007 Sep;75(9):4245-54. doi: 10.1128/IAI.00031-07. Epub 2007 Jun 11. Infect Immun. 2007. PMID: 17562768 Free PMC article.
The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia.
Witzenrath M, Pache F, Lorenz D, Koppe U, Gutbier B, Tabeling C, Reppe K, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B. Witzenrath M, et al. Among authors: mitchell tj. J Immunol. 2011 Jul 1;187(1):434-40. doi: 10.4049/jimmunol.1003143. Epub 2011 Jun 6. J Immunol. 2011. PMID: 21646297
Biological properties of pneumolysin.
Mitchell TJ, Andrew PW. Mitchell TJ, et al. Microb Drug Resist. 1997 Spring;3(1):19-26. doi: 10.1089/mdr.1997.3.19. Microb Drug Resist. 1997. PMID: 9109093 Review.
438 results