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The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates.
Roher AE, Kokjohn TA, Esh C, Weiss N, Childress J, Kalback W, Luehrs DC, Lopez J, Brune D, Kuo YM, Farlow M, Murrell J, Vidal R, Ghetti B. Roher AE, et al. Among authors: lopez j. J Biol Chem. 2004 Feb 13;279(7):5829-36. doi: 10.1074/jbc.M311380200. Epub 2003 Nov 26. J Biol Chem. 2004. PMID: 14645225 Free article.
TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation.
Van Vickle GD, Esh CL, Kalback WM, Patton RL, Luehrs DC, Kokjohn TA, Fifield FG, Fraser PE, Westaway D, McLaurin J, Lopez J, Brune D, Newel AJ, Poston M, Beach TG, Roher AE. Van Vickle GD, et al. Among authors: lopez j. Biochemistry. 2007 Sep 11;46(36):10317-27. doi: 10.1021/bi700951u. Epub 2007 Aug 18. Biochemistry. 2007. PMID: 17705508
Chemical characterization of pro-inflammatory amyloid-beta peptides in human atherosclerotic lesions and platelets.
Kokjohn TA, Van Vickle GD, Maarouf CL, Kalback WM, Hunter JM, Daugs ID, Luehrs DC, Lopez J, Brune D, Sue LI, Beach TG, Castaño EM, Roher AE. Kokjohn TA, et al. Among authors: lopez j. Biochim Biophys Acta. 2011 Nov;1812(11):1508-14. doi: 10.1016/j.bbadis.2011.07.004. Epub 2011 Jul 20. Biochim Biophys Acta. 2011. PMID: 21784149 Free PMC article.
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Salloway S, et al. N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. N Engl J Med. 2014. PMID: 24450891 Free PMC article. Clinical Trial.
Statin therapy in Alzheimer's disease.
Sparks DL, Sabbagh M, Connor D, Soares H, Lopez J, Stankovic G, Johnson-Traver S, Ziolkowski C, Browne P. Sparks DL, et al. Among authors: lopez j. Acta Neurol Scand Suppl. 2006;185:78-86. doi: 10.1111/j.1600-0404.2006.00689.x. Acta Neurol Scand Suppl. 2006. PMID: 16866915 Review.
7,104 results