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Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L, Fried G, Jovanovic JN, Seeger M, Relkin NR, Liao F, Checler F, Buxbaum JD, Chait BT, Thinakaran G, Sisodia SS, Wang R, Greengard P, Gandy S. Xu H, et al. Among authors: sisodia ss. Nat Med. 1998 Apr;4(4):447-51. doi: 10.1038/nm0498-447. Nat Med. 1998. PMID: 9546791
BMS-708,163 targets presenilin and lacks notch-sparing activity.
Crump CJ, Castro SV, Wang F, Pozdnyakov N, Ballard TE, Sisodia SS, Bales KR, Johnson DS, Li YM. Crump CJ, et al. Among authors: sisodia ss. Biochemistry. 2012 Sep 18;51(37):7209-11. doi: 10.1021/bi301137h. Epub 2012 Sep 4. Biochemistry. 2012. PMID: 22931393 Free PMC article.
Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.
Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Wagner SL, et al. Among authors: sisodia ss. Biochemistry. 2014 Feb 4;53(4):702-13. doi: 10.1021/bi401537v. Epub 2014 Jan 22. Biochemistry. 2014. PMID: 24401146 Free PMC article.
Mice deficient for the amyloid precursor protein gene.
Zheng H, Jiang M, Trumbauer ME, Hopkins R, Sirinathsinghji DJ, Stevens KA, Conner MW, Slunt HH, Sisodia SS, Chen HY, Van der Ploeg LH. Zheng H, et al. Among authors: sisodia ss. Ann N Y Acad Sci. 1996 Jan 17;777:421-6. doi: 10.1111/j.1749-6632.1996.tb34456.x. Ann N Y Acad Sci. 1996. PMID: 8624124
Alzheimer's disease: genetic studies and transgenic models.
Price DL, Tanzi RE, Borchelt DR, Sisodia SS. Price DL, et al. Among authors: sisodia ss. Annu Rev Genet. 1998;32:461-93. doi: 10.1146/annurev.genet.32.1.461. Annu Rev Genet. 1998. PMID: 9928488 Review.
236 results